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A Complex Case of Acute Liver Failure Following Idiosyncratic Drug-Induced Liver Injury, Potentiated by Herpes Simplex Virus Infection.
Cureus
December 2024
Internal Medicine, Unidade Local de Saúde de São José, Lisbon, PRT.
Acute liver failure (ALF) is a rare, life-threatening condition that may be secondary to drug-induced liver injury (DILI) and certain viral infections. We present the case of a 73-year-old male with a history of fibrotic hypersensitivity pneumonitis with a progressive phenotype, type 2 diabetes mellitus, hypertension, and hyperlipidemia, who was admitted with ALF potentially secondary to DILI. Prior to admission, he was receiving therapy that may be related to idiosyncratic DILI (I-DILI) and ALF, namely nintedanib, which appears to have a most probable relation to I-DILI in this case, considering it was the most recently started drug.
View Article and Find Full Text PDFIdiosyncratic acute liver failure induced by Tirzepatide.
J Gastrointestin Liver Dis
December 2024
Gastroenterology Department, Southampton General Hospital, Southampton, UK.
Primary Iliopsoas Abscess and Drug-Induced Liver Injury in the Emergency Department: A Case Report.
Diseases
December 2024
Department of Cardiology, "Victor Babes" University of Medicine and Pharmacy, E. Murgu Square No. 2, 300041 Timisoara, Romania.
Background And Objective: Iliopsoas abscess (IPA) is a rare condition with varied symptomology and etiology. Less than one-third of patients with IPA present in the emergency department (ED) with the traditional triad of fever, back pain, and restricted hip motion (or limp), leading to delays in diagnosis and management. Acute liver failure is also a rare clinical presentation in the ED, being associated with high morbidity and mortality.
View Article and Find Full Text PDFA Rare Case of Pulmonary Edema Secondary to Hydrochlorothiazide Use.
Case Rep Crit Care
November 2024
Department of Internal Medicine, Los Angeles General Medical Center, Los Angeles, California, USA.
Noncardiogenic pulmonary edema has been reported as a rare adverse reaction of hydrochlorothiazide. Symptoms can develop acutely after medication ingestion, and patients may present acutely ill. The mechanism by which hydrochlorothiazide causes pulmonary edema remains unknown and is considered idiosyncratic.
View Article and Find Full Text PDFDrug-induced acute kidney injury: a cohort study on incidence, identification of pathophysiological mechanisms, and prognostic factors.
Front Med (Lausanne)
October 2024
Hospital das Clínicas, Faculdade de Medicina de Botucatu, Botucatu, Brazil.
Article Synopsis
- Acute Kidney Injury (AKI) is a serious condition marked by a sudden decrease in kidney function (measured by GFR), often influenced by nephrotoxic drugs, especially in hospitalized patients.
- There are two main types of drug-induced reactions: Type A, which are predictable and dose-dependent leading to Acute Tubular Necrosis, and Type B, which are unpredictable and idiosyncratic leading to conditions like Acute Interstitial Nephritis.
- The study aims to assess the incidence of Drug-Induced Acute Kidney Injury (DI-AKI), identify key offending drugs, understand the mechanisms behind the injury, and evaluate outcomes like mortality and need for kidney support therapy compared to other forms of AKI.
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