There is a lack of an effective prognostic model for predicting outcomes in patients with primary pulmonary hypertension (PPH). A retrospective analysis was conducted on PPH patients from MIMIC and eICU databases. A predictive model was developed to assess mortality risk. The Consistency Index (C-index) and Receiver Operating Characteristic (ROC) curve were utilized to assess the overall performance of the model and its discriminatory capacity. The model's calibration and clinical applicability were assessed through calibration curve and decision curve analysis (DCA). The nomogram was employed for visual representation of the model. The study included 420 patients, 260 in the development group, 104 in the internal validation group and 56 in the external validation group. The predictive model's risk factors included age, respiratory rate, red blood cell distribution width, glucose, and SAPS II. The model demonstrated C-indexes of 0.736 and 0.696 in the development and internal validation groups, respectively. The ROC curves for the development, internal validation and external validation groups demonstrated robust discriminatory capabilities. The calibration curves indicated a slope close to 1, suggesting good calibration of the model. Additionally, DCA analysis revealed the model offered significant clinical benefits across a wide range of thresholds. The model showed good discrimination ability, accuracy and clinical application value in predicting the prognosis of patients with PPH.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-024-83139-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682143PMC

Publication Analysis

Top Keywords

internal validation
12
model
9
predictive model
8
patients primary
8
primary pulmonary
8
pulmonary hypertension
8
validation group
8
external validation
8
development internal
8
validation groups
8

Similar Publications

The purpose of this study was to evaluate the psychometric properties of the Chinese version of the Revised Indebtedness Scale (IS-R-C) in mainland China. A total of 1057 university students participated in this study using a two-wave whole-group sampling method. Sample 1, consisting of 537 participants, was used for item analysis and exploratory factor analysis (EFA) of the Revised Indebtedness Scale (IS-R).

View Article and Find Full Text PDF

Psychometric properties of the English and Hindi versions of the Brief Inventory of Thriving for use among Indian adolescents.

Sci Rep

December 2024

Faculty of Education, Centre for Wellbeing Science, The University of Melbourne, Level 2, 100 Leicester Street, Carlton, VIC, 3010, Australia.

The Brief Inventory of Thriving (BIT) provides a holistic measure of well-being, but has only been validated for adults, and does not have a Hindi version. The present study investigated the unidimensional structure, internal consistency, convergent/discriminant, and criterion validity of both the original English version of the BIT (BIT-E) and its Hindi-translated version (BIT-H) among adolescents in India. Further, we tested measurement invariance across these two language versions, gender, and academic disciplines.

View Article and Find Full Text PDF

Validity and Reliability of the Videoconference-Based Berg Balance Scale in Stroke Survivors: The Tele-Berg Balance Scale.

J Neurol Phys Ther

December 2024

Department of Physical Therapy, Motor Control Laboratory (LADECOM), Centre of Healthy and Sport Sciences, University of Santa Catarina State, Florianópolis, Santa Catarina, Brazil.

Background And Purpose: Telerehabilitation represents an alternative for individuals who have difficulty accessing services to receive care. Therefore, telerehabilitation measures must be studied for their reliability and validity. This study evaluated the validity and reliability of the videoconference-based Berg Balance Scale assessment in stroke survivors.

View Article and Find Full Text PDF

Background: Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates of autoimmunity and severe complications from infections. Although it is well established that T21 causes increased interferon responses and JAK/STAT signaling, elevated autoantibodies, global immune remodeling, and hypercytokinemia, the interplay between these processes, the clinical manifestations of DS, and potential therapeutic interventions remain ill defined.

Methods: We report a comprehensive analysis of immune dysregulation at the clinical, cellular, and molecular level in hundreds of individuals with DS, including autoantibody profiling, cytokine analysis, and deep immune mapping.

View Article and Find Full Text PDF

Objectives: The aim of this study was to adapt and apply the Portuguese version of the Transgender Man Voice Questionnaire in a sample of Brazilian transgender men and to investigate the relationship between voice satisfaction and hormone therapy duration. In addition, we suggest reducing and reformulating the questionnaire for screening.

Methods: We conducted a cross-sectional study of 31 transgender men aged 18-50 years undergoing hormone therapy who answered a questionnaire adapted from the Transgender Woman Voice Questionnaire, validated in Portuguese.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!