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Zopiclone Overdose Is an Important and Under-Recognized Cause of Drug-Induced Oxidative Hemolysis: A Case Series Identified by Heinz Body Test Request.
Int J Lab Hematol
December 2024
Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong.
Probe Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantification of Benzodiazepines.
Ther Drug Monit
August 2024
Department of Pharmacology and Toxicology, Limoges University Hospital, Limoges ,France ; and.
Background: Legally prescribed benzodiazepines (BZDs) and designer BZDs are widely misused and must be determined in multiple contexts (eg, overdose, drug-facilitated sexual assaults, or driving under the influence of drugs). This study aimed to develop a method for measuring serum BZD levels using probe electrospray ionization (PESI) mass spectrometry and an isotope dilution approach.
Methods: A tandem mass spectrometer equipped with a probe electrospray ionization source in multiple reaction monitoring mode was used.
Zopiclone-Induced Methemoglobinemia: A Case Report Highlighting How the Treatment Differs in Patients on Serotonergic Medication.
Cureus
February 2024
General Medicine, Sengkang General Hospital, Singapore, SGP.
Zopiclone is a sedative-hypnotic that is increasingly being used for insomnia, especially among patients with depression. The side effects of zopiclone include nausea, vomiting, headache, giddiness, sedation, altered mental status, and coma. Here, we describe a rare case of a patient with underlying depression who overdosed on zopiclone, resulting in a presentation of drowsiness and dyspnea.
View Article and Find Full Text PDFDetection of drugs and hepatitis C virus in used syringes from a needle exchange in Gothenburg, Sweden.
Drug Test Anal
September 2024
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
People who inject drugs (PWID) are exposed to serious health risks such as lethal overdoses, addiction and infections. The patterns of drug use and the prevalence of hepatitis C virus (HCV) infection vary greatly between and even within countries. Data on drugs used for injection are important to inform PWID of risks and adapt healthcare.
View Article and Find Full Text PDFPharmacobezoar-Related Fatalities: A Case Report and a Review of the Literature.
Ther Drug Monit
February 2024
Service de Pharmacologie-Toxicologie et Pharmacovigilance, Centre Hospitalo-Universitaire, Angers, France.
Pharmacobezoars develop after an acute overdose or during routine drug administration. Here, the authors present a case of fatal multidrug overdose involving a 62-year-old woman. Her usual treatment included tramadol extended-release, citalopram, and mirtazapine.
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