Unconventional gas reservoirs, characterized by their complex geologies and challenging extraction conditions, demand innovative approaches to enhance gas production and ensure economic viability. Well stimulation techniques, such as hydraulic fracturing and acidizing, have become indispensable tools in unlocking the potential of these tight formations. However, the effectiveness of these techniques can vary widely depending on the specific characteristics of the reservoir. In this context, a data-driven approach to assess well stimulation practices offers a promising avenue to optimize recovery processes and reduce uncertainties. This paper presents a comprehensive study that leverages the power of big data analytics and machine learning to analyze and improve well stimulation strategies in unconventional gas reservoirs. By systematically gathering and processing vast arrays of geological, operational, and production data, this study aims to identify patterns and correlations that can predict stimulation outcomes more accurately. The ultimate goal is to develop a robust framework that allows for tailored stimulation designs based on the unique properties of each reservoir, thereby maximizing efficiency and minimizing environmental impacts. This study introduces a new procedure for assessing well stimulation performance, which involves analyzing the EUR through Duong's model, calculating the key performance indicator of the treatment, and establishing a data-driven model to predict the treatment KPI.
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http://dx.doi.org/10.1038/s41598-024-82454-z | DOI Listing |
J Dermatol Sci
November 2024
Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Background: Mutations in gamma-secretase complex (GSC) genes are associated with hidradenitis suppurativa (HS), and toll-like receptor (TLR) 2 is elevated in HS lesions. However, it remains unclear whether TLR2 is upregulated in the skin lesions of patients with HS with GSC gene variants, and the role of its upregulation in the pathogenesis of this disease are unknown.
Objective: To investigate the role of TLR2 upregulation in NCSTN and PSENEN knockdown keratinocytes.
Neuro Endocrinol Lett
December 2024
Department of Internal Medicine, Tokyo Saiseikai Central Hospital, Minato-ku, Tokyo, Japan.
A 33-year-old Japanese man with a history of atopic dermatitis and asthma had never been diagnosed with any apparent glucose intolerance but had been aware of palpitations for >10 years. A 75g oral glucose tolerance test (OGTT) at his physical examination in March 2021 revealed fasting hyperglycemia and post-load hypoglycemia. An OGTT recheck was performed in May 2021 and was normal.
View Article and Find Full Text PDFAm J Pathol
December 2024
Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:
Tissue inhibitors of metalloproteinases (TIMPs) modulate extracellular matrix (ECM) remodeling for maintaining homeostasis and promoting cell migration and proliferation. Pathological conditions can alter TIMP homeostasis and aggravate disease progression. The roles of TIMPs have been studied in tissue-related disorders; however, their contributions to tissue repair during corneal injury are undefined.
View Article and Find Full Text PDFToxicol Appl Pharmacol
December 2024
Department of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:
The elevated risk of cardiovascular disease (CVD) associated with inflammatory rheumatic diseases has long been recognized. Patients with established rheumatoid arthritis (RA) have a higher mortality rate compared to the general population due to abnormal platelet activation. Thymidine phosphorylase (TYMP) plays a crucial role in platelet activation and thrombosis, following bridging the link between RA and CVD.
View Article and Find Full Text PDFImmunol Lett
December 2024
Department of Emergency, Affiliated Hospital of Zunyi Medical University, 563003 Zunyi, Guizhou, China. Electronic address:
Background: The spleen, as the body's largest peripheral immune organ and a crucial source of circulating monocytes, plays a significant role in the acute inflammatory response of spleen-derived macrophages to diseases. Therefore, studying the impact and mechanism of X-ray irradiation on spleen-derived macrophages' inflammatory responses is of great importance.
Method: Extracted and identified mice splenic macrophages were divided into four groups: control group, LPS and ATP co-stimulated non-irradiated group, LPS and ATP co-stimulated group irradiated after 6h, and LPS and ATP co-stimulated group irradiated after 12h.
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