Past research has demonstrated the association between social engagement and the maintenance of cognitive abilities. However, inconsistent definitions of social engagement have posed challenges to systematically investigate this association. This paper addresses the role of social relationships in cognitive functioning among older adults, focusing on the real-life communication indicator-length of own speech-as a measure of social activity. Utilizing advanced technology to unobtrusively measure older adults' real-life speech, this study investigates its association with various cognitive abilities and sociodemographic factors. Differential cognitive measures, and sociodemographic data including factors like age, sex, education, income, persons living in the same household, loneliness, and subjective hearing status were included. Audio data of 83 participants are analyzed with a machine learning speaker identification algorithm. Using Elastic Net regularized regression, results indicate that higher levels of working memory, cognitive speed, and semantic fluency predict own speech in everyday life. While having no partner negatively predicted own speech length, we unexpectedly found that higher hearing status was related to lower speech frequency. Age was neither a relevant predictor in the regression nor correlated with any other variables. We discuss implications and future research applications based on the findings from our novel approach.
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http://dx.doi.org/10.1038/s41598-024-82144-w | DOI Listing |
Trials
December 2024
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despite the fact that MRSA is rarely implicated in CAP. Conducting polymerase chain reaction (PCR) testing on nasal swabs to identify the presence of MRSA colonization has been proposed as an antimicrobial stewardship intervention to reduce the use of vancomycin. Observational studies have shown reductions in vancomycin use after implementation of MRSA colonization testing, and this approach has been adopted by CAP guidelines.
View Article and Find Full Text PDFMol Cell Neurosci
December 2024
Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Türkiye; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Türkiye; Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Türkiye. Electronic address:
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by the accumulation of amyloid plaques, phosphorylated tau tangles and microglia toxicity, resulting in neuronal death and cognitive decline. Since microglia are recognized as one of the key players in the disease, it is crucial to understand how microglia operate in disease conditions and incorporate them into models. The studies on human microglia functions are thought to reflect the post-symptomatic stage of the disease.
View Article and Find Full Text PDFInt J Pharm
December 2024
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China. Electronic address:
Alzheimer's disease (AD) is a neurodegenerative disease that is significantly characterized by cognitive and memory impairments, which worsen significantly with age. In the late stages of AD, metal ion disorders and an imbalance of reactive oxygen species (ROS) levels occur in the brain microenvironment, which causes abnormal aggregation of β-amyloid (Aβ), leading to a significant worsening of the AD symptoms. Therefore, we designed a composite nanomaterial of macrophage membranes-encapsulated Prussian blue nanoparticles (PB NPs/MM).
View Article and Find Full Text PDFJ Autism Dev Disord
December 2024
Department of Psychology, University of Cambridge, Cambridge, UK.
Purpose: This study explored the narrative coherence of the accounts of an experienced event produced by autistic and neurotypical children (ages 6-15 years) after delays of two weeks and two months.
Methods: The sample comprised 27 autistic children and 32 neurotypical peers, who were interviewed about the event using the Revised National Institute of Child Health and Human Development (NICHD) Investigative Interview Protocol. The study focused on assessing the narrative coherence of children's reports, emphasizing key story grammar elements and temporal features in their narratives.
Psychol Res
December 2024
Brain and Cognition, KU Leuven, Leuven, Belgium.
Researchers in numerical cognition have extensively studied the number sense-the innate human ability to extract numerical information from the environment quickly and effortlessly. Much of this research, however, uses abstract stimuli (e.g.
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