The traditional optimization approaches suffer from certain problems like getting stuck in local optima, low speed, susceptibility to local optima, and searching unknown search spaces, thus requiring reliance on single-based solutions. Herein, an Improved Aquila Optimizer (IAO) is proposed, which is a unique meta-heuristic optimization method motivated by the hunting behavior of Aquila. An improved version of Aquila optimizer seeks to increase effectiveness and productivity. IAO emulates the hunting behaviors of Aquila, elucidating each step of the hunting process. The IAO algorithm contains innovative elements to boost its optimization capabilities. It combines a combination of low flight with a leisurely descent for exploitation, high-altitude vertical dives, contour flying with brief gliding attacks for exploration, and controlled swooping maneuvers for effective prey capture. To assess the effectiveness of IAO, Herein, numerous experiments were carried out. Firstly, IAO was compared using 23 classical optimization functions. The achieved results demonstrate that the proposed model outperforms various champion algorithms. Secondly, the proposed algorithm is applied to five real-world engineering problems. The achieved results prove effectiveness in diverse application domains. The key findings of the research work highlight IAO's resilience and adaptability in solving challenging optimization issues and its importance as a strong optimization tool for real-world engineering applications. Convergence curves compare the speed of proposed algorithms with selected algorithms for 1000 iterations. Time complexity analysis shows that the best time is 0.00015225 which is better as compared to other algorithms also Wilcoxon ranksum test is carried out to calculate the p-value is less than 0.05 rejecting the null hypothesis. The research emphasizes the potential of IAO as a tool for tackling real-world optimization challenges by explaining its efficacy and competitiveness compared to other optimization procedures via comprehensive testing and analysis.
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http://dx.doi.org/10.1038/s41598-024-79577-8 | DOI Listing |
Sci Rep
December 2024
Department of Computer Science, College of Computer and Information Sciences, King Saud University, 11543, Riyadh, Saudi Arabia.
The traditional optimization approaches suffer from certain problems like getting stuck in local optima, low speed, susceptibility to local optima, and searching unknown search spaces, thus requiring reliance on single-based solutions. Herein, an Improved Aquila Optimizer (IAO) is proposed, which is a unique meta-heuristic optimization method motivated by the hunting behavior of Aquila. An improved version of Aquila optimizer seeks to increase effectiveness and productivity.
View Article and Find Full Text PDFFree Radic Biol Med
December 2024
Dept. of Cancer Biology, Loyola University Chicago, Maywood, IL, 60153, USA. Electronic address:
Mounting evidence shows that tumor growth and progression rely on thioredoxin reductase 1 (TXNRD1)-mediated detoxification of oxidative stress that results from deregulated metabolism and mitogenic signaling in tumors. TXNRD1 levels are significant higher in triple negative breast cancer (TNBC) compared to normal tissue, making TXNRD1 a compelling TNBC therapeutic target. Despite the many attempts to generate TXNRD1 inhibitors, all known and reported compounds inhibiting TXNRD1 are problematic; they interact with TXNRD1 irreversibly and non-specifically resulting in numerous adverse side effects.
View Article and Find Full Text PDFSci Rep
December 2024
State Grid Xinjiang Electric Power Co., Ltd. Extra-High Voltage Branch Company, Urumqi, 830002, Xinjiang, China.
To accommodate China's electricity market reforms integrating medium and long-term (MLT) transactions and spot transactions, and to boost renewable energy consumption through the spot market, this paper proposes an optimized cross-provincial electricity trading strategy model based on a two-layer game framework. The proposed model incorporates an MLT green certificate contract decomposition method, enabling nested optimization of green certificate contracts and scheduling plans for cross-provincial power transactions. To encourage broader participation, a bilateral green certificate trading framework is established, which globally optimizes green certificate allocation to increase benefits for market participants.
View Article and Find Full Text PDFExpert Rev Med Devices
December 2024
Department of Urology, Rush University Medical Center, Chicago, IL, USA.
Introduction: Recent advancements in single-port surgery, robotic platforms, 3D models and artificial intelligence have transformed surgical procedures, especially in urology. These innovations enhance precision, safety, and efficacy, reducing invasiveness and recovery times. The review focuses on the latest in robotic-assisted surgery for genitourinary cancers, highlighting the shift toward personalized, minimally invasive treatments.
View Article and Find Full Text PDFWe present the case of a successful application of combined adductor canal block (ACB) and sacral erector spinae plane (S-ESP) block for the management of a patient suffering from severe hemophilia A with an end-stage arthropathy who underwent total knee replacement. The implementation of a tailored protocol, not incorporating neuraxial techniques, such as spinal anesthesia, facilitated optimal intra- and postoperative pain management and expedited postoperative recovery and rehab without motor weakness and side effects, highlighting the potential benefit of such strategy in selected cases.
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