-Terphenyl compounds are known to possess a diverse range of biological activities, making the synthesis of novel -terphenyl derivatives a significant research objective. In this study, we report the first synthesis of nocarterphenyl A (), characterized by a thiazole-fused -terphenyl framework. Furthermore, we synthesized 18 additional analogs, including the naturally occurring compound 5-methoxy-4,7-bis(4-methoxyphenyl)benzo[]thiazol-6-ol (), employing a similar synthetic approach. Notably, compounds , , -, and demonstrated potent inhibitory effects against protein tyrosine phosphatase 1B (PTP1B), exhibiting IC values ranging from 2.2 to 7.9 μM, which are lower than that of oleanolic acid (13.2 μM). Additionally, compound was found to inhibit α-glucosidase from human colorectal adenocarcinoma (Caco-2) cells with an IC value of 10.4 μM, which is also lower than that of acarbose (11.2 μM).
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