Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.diff.2024.100833 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
WNT16 primer.
Differentiation
December 2024
Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address:
Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2.
BMC Genet
April 2013
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Background: The discovery of TCF7L2 as a global type 2 diabetes (T2D) gene has sparked investigations to explore the clinical utility of its variants for guiding the development of new diagnostic and therapeutic strategies. However, interpreting the resulting associations into function still remains unclear. Canonical Wnt signaling regulates β-catenin and its binding with TCF7L2, which in turn is critical for the production of glucagon-like peptide-1 (GLP-1).
View Article and Find Full Text PDFWnt genes in the mouse uterus: potential regulation of implantation.
Biol Reprod
May 2009
Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.
Wnt genes are involved in critical developmental and growth processes. The present study comprehensively analyzed temporal and spatial alterations in Wnt and Fzd gene expression in the mouse uterus during peri-implantation of pregnancy. Expression of Wnt4, Wnt5a, Wnt7a, Wnt7b, Wnt11, Wnt16, Fzd2, Fzd4, and Fzd6 was detected in the uterus during implantation.
View Article and Find Full Text PDFComprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study.
Blood
April 2007
Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano PN, Italy.
IGHV3-21-using chronic lymphocytic leukemia (CLL) is a distinct entity with restricted immunoglobulin gene features and poor prognosis and is more frequently encountered in Northern than Southern Europe. To further investigate this subset and its geographic distribution in the context of a country (Italy) with both continental and Mediterranean areas, 37 IGHV3-21 CLLs were collected out of 1076 cases enrolled by different institutions from Northern or Central Southern Italy. Of the 37 cases, 18 were identified as homologous (hom)HCDR3-IGHV3-21 CLLs and were found almost exclusively (16 of 18) in Northern Italy; in contrast, 19 nonhomHCDR3-IGHV3-21 cases were evenly distributed throughout Italy.
View Article and Find Full Text PDFThe effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line.
Haematologica
June 2006
Laboratory of Hematology and Oncology, Department of Pediatrics, University of Padova, Italy.
Background And Objectives: A common non-random translocation in childhood pre-B acute lymphoblastic leukemia (ALL) is t(1;19)(q23;p13), usually resulting in the expression of the chimeric gene E2A-PBX1. The role of this fusion gene during leukemogenesis is not yet fully understood; one approach to investigate its function is to selectively deplete the E2A-PBX1 protein and examine the consequences.
Design And Methods: We tested the efficacy of anti-E2A-PBX1 siRNA in the 697 pre-B leukemia cell line.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!