Redundancy and maintainability-supported fault-tolerant machining systems are used in many industries to achieve pre-specified reliability and system capability. In this investigation, a non-Markov model for the machining system has been developed by involving the concepts of server vacation, server breakdown, and reboot process. The server may fail and undergo primary repair which may be unsuccessful in recovering the server. In case of imperfect server repair, an additional repair is also performed to bring the server back into functional mode. By using the supplementary variable for the residual repair, we obtain the analytic solution of the finite population M/G/1 queueing model for the performance prediction of FTMS. The method of parametric non-linear programming has been implemented to evaluate the performance measures in both crisp and fuzzy environments. The meta-heuristic approaches PSO, GA and classical optimization technique quasi-Newton method are employed to determine the optimal design descriptors by minimizing the total cost. The sensitivity of performance indices with respect to system parameters has been examined for the specific repair time distributions by taking illustrations.
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http://dx.doi.org/10.1016/j.isatra.2024.12.006 | DOI Listing |
Biochem Pharmacol
December 2024
Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan; Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, Taichung 40402, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu 30205, Taiwan. Electronic address:
Chondrosarcoma is a type of bone cancer that originates from cartilage cells. In clinical practice, surgical resection is the primary treatment for chondrosarcoma, but chemotherapy becomes essential for patients with metastasis or tumors in surgically inaccessible sites. However, drug resistance often leads to treatment failure.
View Article and Find Full Text PDFComput Methods Programs Biomed
December 2024
School of Communication and Information Engineering, Shanghai University, 200444, Shanghai, China. Electronic address:
Background And Objectives: In the current global health landscape, there is an increasing demand for rapid and accurate assessment of mental states. Traditional assessment methods typically rely on face-to-face interactions, which are not only time-consuming but also highly subjective. Addressing this issue, this study aims to develop a client-server-based, non-contact multimodal emotion and behavior recognition system to enhance the efficiency and accuracy of mental state assessments.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
December 2024
Laboratory of Applied Toxicology, Center of Toxins, Immune-Response and Cell Signaling - CeT-ICS/CEPID, Butantan Institute São Paulo, São Paulo, SP CEP 05503-900, Brazil; Postgraduate Program Interunits in Biotechnology, USP/IPT/IBU, São Paulo, SP, Brazil. Electronic address:
Background: Irresponsible and wholesale use of antimicrobial agents is the principal cause of the emergence of strains of resistant microorganisms to traditional drugs. Oligoventin is a neutral peptide isolated from spider eggs of Phoneutria nigriventer, with antimicrobial activity against Gram-positive, Gram-negative, and yeast organisms. However, the molecular target and pathways of antimicrobial activity are still unknown.
View Article and Find Full Text PDFEBioMedicine
December 2024
Department of Anaesthesiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Background: Clinical decision-making is increasingly shifting towards data-driven approaches and requires large databases to develop state-of-the-art algorithms for diagnosing, detecting and predicting diseases. The intensive care unit (ICU), a data-rich setting, faces challenges with high-frequency, unstructured monitor data. Here, we showcase a successful example of a data pipeline to efficiently move patient data to the cloud environment for structured storage.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2024
Pharmacognosy Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
Contamination of water by heavy toxic metal ions such as (e.g., Cr, Mn, Ni, Cu, Zn, As Pb, Cd, and Ag) can lead to serious environmental and human health problems because of their acute and chronic toxicity to the biological system.
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