Objectives: A recent paper by Moore, Lowe and Cox has proposed guidelines for diagnosing noise-induced hearing loss (NIHL). It is referred to here as the MLC guidelines. Our aim was to assess the specificity of those guidelines (i.e., freedom from false-positive outcomes) and compare with pre-existing guidelines.
Design: We applied the MLC guidelines and pre-existing guidelines to three data sets composed of adults who do not have a history of material noise exposure and therefore cannot have NIHL.
Setting: National Health Service (NHS) ENT clinic.
Participants: Five hundred thirty-six patients with hearing difficulty and/or tinnitus who denied material noise exposure. Two large archival population studies of hearing were also assessed, which included 3250 participants without material noise exposure.
Main Outcome Measure: False-positive outcome from guidelines.
Results: The MLC guidelines demonstrated moderate or high false-positive rates overall, the magnitude depending on the noise exposure scenario and whether clinical or population samples were considered. For the procedure applicable to steady broadband noise exposure, the false-positive rate averaged 56% in the population samples, compared to 31% for previous guidelines. For exposure to intense impulse sounds, the MLC guidelines take a different approach and the false-positive rate was about 70% in the population samples and even higher in the clinic sample. For exposure to intense tones, the MLC guidelines take yet another approach and the false-positive rate reached 80%.
Conclusions: The MLC guidelines demonstrate poorer specificity than previous guidelines. Medical experts should be aware of their poor specificity and consequential likelihood of false-positive diagnoses of NIHL.
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http://dx.doi.org/10.1111/coa.14268 | DOI Listing |
Clin Otolaryngol
December 2024
Consultant ENT Surgeon, Department of Otolaryngology Head and Neck Surgery, Manchester Royal Infirmary; Honorary Senior Lecturer, University of Manchester, Manchester, UK.
Objectives: A recent paper by Moore, Lowe and Cox has proposed guidelines for diagnosing noise-induced hearing loss (NIHL). It is referred to here as the MLC guidelines. Our aim was to assess the specificity of those guidelines (i.
View Article and Find Full Text PDFJ Pediatr Pharmacol Ther
December 2024
Department of Clinical Pharmacy and Translational Science (MLC, LA, OH), University of Tennessee Health Science Center, Department of Pediatrics (MLC, MFW), University of Tennessee Health Science Center, Memphis, TN.
Objective: The use of umbilical artery catheters (UACs) for parenteral nutrition (PN) administration is controversial, and limited data exist on the safety of administration through this route. The objective of this research is to evaluate neonates who received PN through a UAC and assess catheter-related complications and PN composition.
Methods: This retrospective study evaluated all neonates who received PN through their UAC while admitted in the neonatal intensive care unit between January 2019 and December 2022.
Int J Cardiol
February 2025
III Infectious Diseases Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy; Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy.
J Pediatr Pharmacol Ther
October 2024
Department of Pediatrics (SJP, JWW) and Division of Neurology (JWW; ORCID 0000-0002-4735-3431), College of Medicine, The University of Tennessee Health Science Center, Memphis TN; and.
Objective: To evaluate age, adjunctive antiseizure medication (ASM), and specific ASMs on lacosamide (LCM) weight normalized dose-to-concentration ratio (DCR) and US Food and Drug Administration (FDA) dosing guidelines in pediatric patients.
Methods: Patients 1 mo to ≤18 years with a LCM serum concentration between October 2009 and June 2017 were considered. Demographics, LCM DCR, and adjunctive ASM were recorded.
J Appl Clin Med Phys
December 2024
Radiation Oncology Department, National Center for Cancer Care and Research, Doha, Qatar.
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