The main objective of this paper is to analyze, through a unique large-scale modeling facility, the RDS wash-off under various scenarios of intense rainfall and high RDS masses. A 1:1 scale physical modeling facility was used to allow precise measurement of the RDS wash-off phenomenon under two different rainfall intensities (30/50 mm/h) and three initial RDS masses (100/150/200 g/m). The accumulated and discharged masses of RDS in the different components of the modeling facility (roadway/RW, gully pot/GP and manhole/MH) were collected at the end of the wash-off simulations. The results suggested the following sequence of intervention in the components of the drainage system to control pollution associated with fine RDS (< 63 μm): MH (59.2 %) > GP (31.2 %) > RW (9.6 %). The wash-off simulations suggested the following maximum (30/68 g/m), minimum (16/38 g/m) and minimum (2.15/2.61 g/m) limits on the mass of RDS remaining on the RW, removed by the GP and discharged into the MH, respectively. These mass limits were relevant to understand the RDS behavior and to suggest improvement strategies for the RW cleaning systems (coarse/fine fractions washed-off: 80.3/81.7 %), GPs (coarse/fine fractions removed: 75.3/49.6 %) and MHs (coarse/fine fractions discharged: 5/32.1 %). Finally, the results suggested that the size fractions <63 μm and between 500 and 1000 μm were representative of the wash-off for the finest and coarsest fractions of the RDS, respectively.
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http://dx.doi.org/10.1016/j.scitotenv.2024.178195 | DOI Listing |
Sci Rep
December 2024
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222-1 Wangsimni-ro, Seongdong-Gu, Seoul, 04763, Korea.
Limited knowledge exists regarding biomarkers that predict treatment response in Lupus nephritis (LN). We aimed to identify potential molecular biomarkers to predict treatment response in patients with LN. We enrolled 66 patients with active LN who underwent renal biopsy upon enrollment.
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December 2024
Department of Biochemistry, Faculty of Science, Mahidol University, 272 Rama VI Road, Thung Phayathai, Ratchathewi, Bangkok, 10400, Thailand.
Wnt signaling is a critical pathway implicated in cancer development, with Frizzled proteins, particularly FZD10, playing key roles in tumorigenesis and recurrence. This study focuses on the potential of repurposed FDA-approved drugs targeting FZD10 as a therapeutic strategy for nasopharyngeal carcinoma (NPC). The tertiary structure of human FZD10 was constructed using homology modeling, validated by Ramachandran plot and ProQ analysis.
View Article and Find Full Text PDFReduced bacteria concentrations in wastewater is a key indicator of the efficacy of water resource recovery facilities (WRRFs). However, monitoring the presence of bacterial concentrations in real time at each stage of the WRRF is challenging as it requires taking and processing water samples offline. Although few studies have been proposed to predict bacterial concentrations using data-driven models, generalizing these models to unseen data from different WRRFs remains challenging.
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December 2024
University of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, 75308, Vietnam.
Oxidative stress, characterized by the damaging accumulation of free radicals, is associated with various diseases, including cardiovascular, neurodegenerative, and metabolic disorders. The transcription factor Nrf2 is pivotal in cellular defense against oxidative stress by regulating genes that detoxify free radicals, thus maintaining redox homeostasis and preventing cellular aging. Keap1 plays a regulatory role through its interaction with Nrf2, ensuring Nrf2 degradation under homeostatic conditions and facilitating its stabilization and nuclear translocation during oxidative stress.
View Article and Find Full Text PDFInt Breastfeed J
December 2024
Department of Community and Family Medicine, All India Institute of Medical Sciences, Bathinda (Punjab), Bathinda, 151001, India.
Background: Exclusive breastfeeding (EBF) is defined as feeding infants only breast milk of the mother or a wet nurse for the first six months, without additional food or liquids except the oral rehydration solution or drops/syrups of vitamins, minerals or medicines. The working status of women in developed countries adversely affects the EBF rates, which calls for an assessment in rapidly developing countries like India. Therefore, the primary aim of the present study is to determine the prevalence of EBF using the data from the National Family Health Surveys (NFHS 3, 4, 5) conducted between 2005 and 06, 2015-16 and 2019-21 to estimate the likelihood EBF according to mothers' employment status.
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