Unlabelled: The article is devoted to the problem of the rehabilitation stage of cochlear implantation in patients with inner ear abnormalities. It provides a detailed analysis of the audiological characteristics of such patients and draws conclusions about approaches to interpreting diagnostic data and speech processors fitting.
Material And Methods: The track records of 80 patients with abnormalities of the inner ear development were retrospectively studied, of which 10 had abnormal structure of the auditory nerve. At the surgical and rehabilitation stages, patients underwent analysis of the results of implant telemetry, neural response telemetry, speech processor fitting maps, and the results of subjective audiological testing. The results were compared with those of 50 patients (control group) with normal inner ear anatomy and congenital deafness etiology.
Results: The resistance figures of the electrode circuit in patients with abnormalities of the inner ear and normal anatomy did not differ statistically significantly (T=0.86, >0.05). The ability to register the eCAP turned out to be significantly lower in patients with cochlear malformations and had a pattern with the degree of pathological development of the organ (T=10.2; <0.05). The distinctive features of the fitting maps of speech processors in different groups were also revealed, as well as the results of audiological testing.
Conclusions: Patients with abnormalities in the development of the inner ear have distinctive electrophysiological characteristics that are important during the rehabilitation stage of cochlear transplantation. When configuring speech processors, it makes sense to resort to using CIS coding strategies, reducing the dynamic range by increasing the minimum stimulation threshold, and increasing compression.
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http://dx.doi.org/10.17116/otorino2024890614 | DOI Listing |
Vestn Otorinolaringol
December 2024
St. Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russia.
Unlabelled: The article is devoted to the problem of the rehabilitation stage of cochlear implantation in patients with inner ear abnormalities. It provides a detailed analysis of the audiological characteristics of such patients and draws conclusions about approaches to interpreting diagnostic data and speech processors fitting.
Material And Methods: The track records of 80 patients with abnormalities of the inner ear development were retrospectively studied, of which 10 had abnormal structure of the auditory nerve.
Hum Mol Genet
December 2024
Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, No. 1 Shanghai Road, Gulou District, Nanjing 210029, China.
The NC_000006.12: g.34887814C>G variant in TAF11 was identified as a potential functional variant in a Chinese pedigree including two non-syndromic cleft lip only (NSCLO) cases.
View Article and Find Full Text PDFBiotechnol J
December 2024
Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.
The use of optogenetic tools offers an excellent method for spatially and temporally regulated gene and protein expression in cell therapeutic approaches. This could be useful as a concomitant therapeutic measure, especially in small body compartments such as the inner ear, for example, during cochlea implantation, to enhance neuronal cell survival and function. Here, we used the blue light activatable CRY2/CIB system to induce transcription of brain-derived neurotrophic factor (BDNF) in human cells.
View Article and Find Full Text PDFMol Neurobiol
December 2024
Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China.
Noise exposure is one of the most common causes of sensorineural hearing loss. Although many studies considered inflammation to be a major contributor to noise-induced hearing loss, the process of cochlear inflammation is still unclear. Studies have found that activation of the NF-κB signaling pathway results in the accumulation of macrophages in the inner ear plays an important role in hair cell damage.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
December 2024
ENT Department, Sydney Adventist Hospital, Sydney, NSW, Australia.
Background: Meniere's disease (MD) is a disabling disease of the inner ear, having a substantial effect on a patient's quality of life. While various postulations regarding its aetiology exists, due to the difficulty with accessing inner ear tissue, there have been limited histological studies in patients with active MD.
Methods: Tissue was collected during labyrinthectomy from 8 patients with intractable MD who had failed medical therapy (22 samples), and 9 patients undergoing translabyrinthine resection of vestibular schwannoma (19 samples).
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