The need for new biomaterials to meet the needs of advanced healthcare therapies is constantly increasing. Polysaccharide-based matrices are considered extremely promising because of their biocompatibility and soft structure; however, their use is limited by their poor mechanical properties. In this light, a strategy for the reinforcement of dextran-based hydrogels and interpenetrated polymer networks (semi-IPNs and IPNs) is proposed, which will introduce multifunctional crosslinkers that can modify the network crosslinking density. Hydrogels were prepared via dextran methacrylation (DexMa), followed by UV photocrosslinking in the presence of diacrylate (NPGDA), triacrylate (TMPTA), and tetraacrylate (PETA) crosslinkers at different concentrations. The effect of these molecules was also tested on DexMa-gellan semi-IPN (DexMa/Ge) and, later, on IPN (DexMa/CaGe), obtained after solvent exchange with CaCl in HEPES and the resulting Ge gelation. Mechanical properties were investigated via rheological and dynamic mechanical analyses to assess the rigidity, resistance, and strength of the systems. Our findings support the use of crosslinkers with different functionality to modulate the properties of polysaccharide-based scaffolds, making them suitable for various biomedical applications. While no significative difference is observed on enriched semi-IPN, a clear improvement is visible on DexMa and DexMa/CaGe systems when TMPTA and NPGDA crosslinker are introduced at higher concentrations, respectively.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675718PMC
http://dx.doi.org/10.3390/gels10120773DOI Listing

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