Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jlr.2024.100734 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Resolving Lipoxin A: Endogenous Mediator or Exogenous Anti-Inflammatory Agent?
J Lipid Res
December 2024
Edward A. Doisy Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO 63104. Electronic address:
Exploring the Unique Role of Specialized Pro-Resolving Mediators in Cancer Therapeutics.
Prostaglandins Other Lipid Mediat
December 2024
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215.
Unresolved chronic inflammation, a hallmark of cancer, promotes tumor growth and metastasis in various cancer types. In contrast to blocking inflammation, stimulation of resolution of inflammation is an entirely novel approach to "resolve" inflammation. Resolution of inflammation mechanisms in cancer includes clearance of tumor debris, counter-regulation of pro-inflammatory eicosanoids and cytokines, and suppression of leukocyte infiltration.
View Article and Find Full Text PDFTAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury.
Acta Neuropathol
December 2024
Centre for Interdisciplinary Pain Medicine, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Nerve injury causes neuropathic pain and multilevel nerve barrier disruption. Nerve barriers consist of perineurial, endothelial and myelin barriers. So far, it is unclear whether resealing nerve barriers fosters pain resolution and recovery.
View Article and Find Full Text PDFIntegration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.
Gut
December 2024
Department of Surgery, University of South Florida Health, Tampa, Florida, USA
Background: Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal wound healing is represented by a transitory phase of inflammation, followed by a pro-resolution phase, with prostaglandin (PGE2/PGD2)-induced 'lipid class switching' producing inflammation-quenching lipoxins (LXA4, LXB4).
Objective: We explored if lipid dysregulation in colorectal cancers (CRCs) is driven by a failure to resolve inflammation.
Attenuation of adipose tissue inflammation by pro-resolving lipid mediators.
Curr Opin Endocr Metab Res
September 2024
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Adipose tissue inflammation drives systemic pathophysiology, for instance, obesity-related cardiometabolic disease. Specialized pro-resolving lipid mediators are a superfamily of endogenously produced lipids that promote the resolution of inflammation, an actively regulated process. New evidence suggests that such lipids (e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!