AI Article Synopsis
- Migrasomes are new organelles important for cell signaling and communication that involve the protein TSPAN4, whose role in cancer is not well understood.
- Researchers studied TSPAN4 across multiple cancer types, examining its expression levels and connections to tumor characteristics using large datasets.
- Findings indicate TSPAN4 is irregularly expressed in tumors, affecting tumor growth and immune response, particularly in glioma, where it encourages an immunosuppressive environment.
Article Abstract
Background: Migrasomes are newly identified organelles on the retracting fibers of migrating cells, involved in releasing signaling molecules, expelling damaged mitochondria, and facilitating intercellular communication through phagocytosis. TSPAN4, a key regulator of migrasome formation, is a valuable marker for visualizing these organelles. However, its role in cancer remains unclear.
Methods: We analyzed TSPAN4 expression and its prognostic significance across multiple cancers using TCGA Pan-Cancer (PANCAN), and TCGA TARGET GTEx datasets. The relationship between TSPAN4 and tumor heterogeneity, stemness, and the immunosuppressive tumor microenvironment was explored through RNA-seq and scRNA-seq data. In addition, we examined TSPAN4's role in glioma, focusing on migrasome formation, cell proliferation, and macrophage polarization.
Results: Our analysis reveals that TSPAN4 is aberrantly expressed in various tumors, likely linked to its methylation status. It correlates with tumor heterogeneity, stemness, and a suppressive immune microenvironment. In glioma, TSPAN4 enhances cell proliferation and promotes macrophage polarization toward the immunosuppressive M2 phenotype.
Conclusions: TSPAN4, as a migrasome regulator, plays a crucial role in shaping the immunosuppressive tumor microenvironment in pan-cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668678 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1419420 | DOI Listing |
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