The Role of Neutrophils in Allergic Disease.

Clin Exp Immunol

Discipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.

Published: December 2024

Neutrophils are short-lived cells of the innate immune system and represent 50-70% of the circulating leucocytes. Their primary role is antimicrobial defence which they accomplish through rapid migration to sites of inflammation followed by phagocytosis, degranulation and the release of neutrophil extracellular traps (NETosis). While previously considered terminally-differentiated cells, they have been shown to have great adaptability and to play a role in conditions ranging from cancer to autoimmunity. This review focuses on their role in allergic disease. In particular: their role as potential amplifiers of type 1 hypersensitivity reactions leading to anaphylaxis; their involvement in alternative pathways of food and drug allergy; their role in allergic rhinitis and asthma and neutrophil dysfunction in atopic dermatitis. The use of potential biomarkers and therapeutic targets is also discussed with a view to guiding future research.

Download full-text PDF

Source
http://dx.doi.org/10.1093/cei/uxae126DOI Listing

Publication Analysis

Top Keywords

allergic disease
8
role allergic
8
role
6
role neutrophils
4
neutrophils allergic
4
disease neutrophils
4
neutrophils short-lived
4
short-lived cells
4
cells innate
4
innate immune
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!