Nowadays, factories located in COVID-19 infected countries/regions are facing random outbreaks. If blockchain is adopted, then the outbreaks can be known immediately and emergency production shifting can be enabled, although high crash cost will be incurred. Otherwise, production delay will become inevitable. We therefore formulate the tradeoffs among the high crash cost, the benefit from quick production, and the efficiency loss because of supply chain decentralization in a global brand's blockchain adoption decisions. We show that, in the presence of supply chain competition, the global brand will be benefited from blockchain adoption when the competition intensity degree is high, the crash cost is low, and the probability of COVID-19 outbreak is high. We then verify the robustness of the main findings by studying the impact of the global brand's risk attitude, its overestimation of production delay, and the unexpected production delay in the low-risk areas. In addition, we examine the social welfare and find it can also benefit from the global brand's blockchain adoption but the consumer surplus cannot.
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http://dx.doi.org/10.1111/risa.14199 | DOI Listing |
J Vis Exp
December 2024
The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Faculty of Health and Medical Sciences, School of Medicine, Tel Aviv University;
Cerebellar Purkinje cells (PCs) exhibit a unique interplay of high metabolic rates, specific chromatin architecture, and extensive transcriptional activity, making them particularly vulnerable to DNA damage. This necessitates an efficient DNA damage response (DDR) to prevent cerebellar degeneration, often initiated by PC dysfunction or loss. A notable example is the genome instability syndrome, ataxia-telangiectasia (A-T), marked by progressive PC depletion and cerebellar deterioration.
View Article and Find Full Text PDFFood Sci Nutr
January 2025
Department of Postharvest, Supply Chain, Commerce and Sensory Science, Institute of Food Science and Technology Hungarian University of Agriculture and Life Sciences Budapest Hungary.
The volatile profile of bee pollen samples from Central and Eastern Europe was investigated by headspace solid phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry-olfactometry (GC-MS-O). Sampling conditions were optimized for the extraction of volatiles. Pollen odorants were extracted with six different fiber coatings, five various extraction times, three diverse extraction temperatures and three differing desorption times.
View Article and Find Full Text PDFClin Nutr ESPEN
January 2025
University of Medical Sciences, Department of Histology and Embryology, Poznań, Poland.
Background & Aims: The developmental origin of health and disease hypothesis shows that early adverse exposures can have lifelong health effects. Thus, the aim of this study was to analyze the impact of choline intake during pregnancy and/or lactation on gene expression profiles in the liver of 24-day-old male rat offspring from dams with non-alcoholic fatty liver disease (NAFLD).
Methods: Phenotypic characteristic, histological examination and global transcriptome pattern of liver tissue specimens obtained from offspring of dams suffering from fatty liver, provided with proper choline intake during pregnancy and lactation (NN), fed a choline-deficient diet during both periods (DD), deprived of choline only during pregnancy (DN), or only during lactation (ND), was performed.
Int J Pharm
January 2025
Pharmaceutical Engineering Research Group (PharmaEng), Department of Pharmaceutical Analysis, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address:
The tablet diversion strategy, based on in-line near-infrared (NIR) tablet press feed frame measurements, can be a key component of both batch and continuous oral solid dose manufacturing processes. It enables real-time, high-frequency monitoring and control, enhancing process understanding and compliance compared to conventional interval-based sampling methods. Central to this strategy are NIR spectrometers, which serve as PAT systems for in-line blend uniformity monitoring in the feed of the tablet press.
View Article and Find Full Text PDFForensic Sci Int
January 2025
King's Forensics, Department of Analytical, Environmental and Forensic Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address:
Wildlife forensics is a relatively underexplored field of science. It provides forensic evidence to support legal investigations involving wildlife crime, such as the trafficking and poaching of animals and/or their goods. The consequences of poaching are not just limited to a decline in animal welfare and include the spread of zoonotic disease, species, cultural and habitat loss, and injury of anti-poaching rangers.
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