This study employed PM concentration data for Xianyang City spanning the years 2014 to 2021, in conjunction with the global data assimilation system (GDAS). Various analytical techniques, including backward trajectory clustering analysis, potential source contribution function (PSCF), concentration weighted trajectory analysis (CWT), and relevant statistical methods, were employed to investigate the temporal and spatial variations in PM pollution. Furthermore, this research aimed to elucidate the source characteristics and potential areas contributing to PM pollution within Xianyang City. The results revealed a fluctuation in PM pollution concentration in Xianyang City from 2014 to 2021, with an initial increase followed by a subsequent decrease. The peak average annual concentration, reaching 81.25 μg·m, was recorded in 2016. Seasonal variations indicated higher PM concentrations in autumn and winter, contrasting with lower levels in spring and summer. Winter exhibited the highest PM concentration at 116 μg·m, while the lowest was recorded in summer at 31.58 μg·m. Spatially, the annual mean distribution of PM in Xianyang City demonstrated heightened pollution in the southern and central regions, juxtaposed with lower pollution in the northern areas. Cluster analysis highlighted that Xianyang City experienced substantial influence from northwest airflow during spring, autumn, and winter, while short-distance transport dominated during the summer months. PSCF and CWT analyses indicated that the high-value potential source contribution areas were most extensive during winter, followed by spring and autumn. Conversely, the high-value area in summer was the smallest. The potential source areas were concentrated within Xianyang City and extended northwest to southeast, encompassing regions in western Inner Mongolia, central and eastern Gansu Province, central and southern Ningxia, and central Henan. In analyzing periods of heavy pollution, the study demonstrated that PM pollution in Xianyang City was primarily induced by westerly airflow. High PM concentrations were influenced by the surrounding areas of Xianyang City and the source zone, akin to regions with high potential source values during the winter. As a consequence, mitigating PM pollution in Xianyang City necessitates stringent control measures for both local and regional pollution sources. Additionally, regional collaborative efforts should be emphasized to prevent external pollution sources from exacerbating persistent pollution episodes in the region.
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http://dx.doi.org/10.13227/j.hjkx.202311165 | DOI Listing |
Invest Ophthalmol Vis Sci
January 2025
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Purpose: Dry eye disease (DED) is a common ocular surface inflammatory disease with a complex pathogenesis. Herein, the role and effect of gasdermin E (GSDME) in DED pathogenesis were explored.
Methods: In vitro, flow cytometry, Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) release assays were used to determine the effects of hyperosmotic stress on pyroptosis, apoptosis, and cell viability in human corneal epithelial cells (HCECs).
J Hypertens
December 2024
Department of Ultrasound Medicine, Tangdu Hospital, Air Force Medical University.
Background: The arterial stiffening is attributed to the intrinsic structural stiffening and/or load-dependent stiffening by increased blood pressure (BP). The respective lifetime alterations and major determinants of the two components with normal aging are not clear.
Methods: A total of 3053 healthy adults (1922 women) aged 18-79 years were enrolled.
Brain Res Bull
January 2025
Department of Joint, Honghui Hospital, Xi'an Jiaotong University, No.555 Youyi East Road, Xi'an City, Shaanxi Province, 710054, PR China. Electronic address:
Background: Electroacupuncture (EA) and trigonelline (TG) have been reported to be beneficial in alleviating cerebral ischemia/reperfusion injury (CIRI). However, the synergistic effects of EA and TG in CIRI and the underlying mechanism have not been demonstrated.
Methods: Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and reperfusion (MCAO/R) to establish a CIRI model.
PLoS One
January 2025
Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Menoufia University, Shibin El-Kom, Egypt.
A serious challenge of the chronic administration of dexamethasone (DEX) is a delay in wound healing. Thus, this study aimed to investigate the potential of Tadalafil (TAD)-loaded proniosomal gel to accelerate the healing process of skin wounds in DEX-challenged rabbits. Skin wounds were induced in 48 rabbits of 4 groups (n = 12 per group) and skin wounds were treated by sterile saline (control), TAD-loaded proniosomal gel topically on skin wound, DEX-injected rabbits, and DEX+TAD-loaded proniosomal gel for 4 weeks.
View Article and Find Full Text PDFInt J Antimicrob Agents
December 2024
Department of Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, China. Electronic address:
Objectives: This study aimed to evaluate the clinical effectiveness of combined aerosolized (AER) and intravenous (IV) polymyxin B in managing patients with hospital-acquired pneumonia (HAP) caused by carbapenem-resistant gram-negative organism (CRO) .
Methods: This multicenter prospective cohort study was conducted across six intensive care units in municipal and above-municipal hospitals in Shaanxi, China, from January 1, 2021 to December 31, 2022. Patients with CRO pneumonia were categorized into the intravenous group (IV polymyxin B alone) and the combination group (AER plus IV polymyxin B).
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