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Analyzing the effect of different storage times and different processes on the volatile components in Shenling Baizhu powder by HS-GC-IMS combined with multivariate statistics.
Anal Methods
January 2025
Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Pharmacy College, Shaanxi University of Chinese Medicine, No. 1, Shiji Avenue, Xi Xian New District, Xi'an City, 712046 Xianyang, Shaanxi Province, China.
Aim: this study aimed to examine the effect of different storage times (0, 7, 24, 57, and 119 days) on the volatile components of Shenling Baizhu powder across different preparation processes (Pharmacopoeia, ultra-micro pulverization-pulverization, and microparticle design methods). The findings offer insights to guide quality control measures for Shenling Baizhu powder.
Methods: gas chromatography-ion mobility spectrometry (GC-IMS) was employed to ascertain the volatile components in Shenling Baizhu powder at various storage times across different preparation processes.
Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants.
Mar Drugs
January 2025
Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA Faculty of Sciences and Technology, NOVA University of Lisbon, Campus Caparica, 2829-516 Caparica, Portugal.
Pigment production has a substantial negative impact on the environment, since mining for natural pigments causes ecosystem degradation, while synthetic pigments, derived from petrochemicals, generate toxic by-products that accumulate and persist in aquatic systems due to their resistance to biodegradation. Despite these challenges, pigments remain essential across numerous industries, including the cosmetic, textile, food, automotive, paints and coatings, plastics, and packaging industries. In response to growing consumer demand for sustainable options, there is increasing interest in eco-friendly alternatives, particularly bio-based pigments derived from algae, fungi, and actinomycetes.
View Article and Find Full Text PDFForecasting the development of antimicrobial resistance of .
Front Oral Health
January 2025
Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine.
Unlabelled: Today, about 15.0% of odontogenic pathology is caused by (). The aim of the study was to predict the development of antimicrobial resistance of based on retrospective data.
View Article and Find Full Text PDFPricing for Multi-Indication Drugs in the Italian Regulatory Context.
Pharmacoecon Open
January 2025
HTA & Pharmaceutical Economics Department, Italian Medicines Agency (AIFA), Rome, Italy.
Background: The authorization of new therapeutic indications for drugs already reimbursed by the Italian National Health Service (NHS) represents a matter of importance. This study aims to estimate the additional discount attributed to the extension of indications (EoIs) to explore the potential correlation between spending and negotiated discounts and to find specific factors (determinants) that impact on discount.
Methods: The study focused on drugs approved in Italy between 2003 and 2017 with at least four therapeutic indications, including the first approved and EoIs, with follow-up extended until 2021 to acquire all the information on the negotiation process that has been completed.
Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV database 3.0.
Front Nutr
January 2025
Department of Immunology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China (UESTC), Mianyang, Sichuan, China.
Purpose: We aim to ascertain the extent to which the blood urea nitrogen (BUN) to serum albumin (ALB) ratio (BAR) could be implemented to anticipate the short- and long-term prognosis of acute ischemic stroke (AIS) patients in intensive care units (ICUs).
Methods: The data was derived from the Marketplace for Intensive Care Medical Information-IV (MIMIC-IV v3.0) database, primarily pertaining to AIS patients as categorized by the International Classification of Diseases (ICD)-9 and ICD-10.
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