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Is creatine useful as adjuvant in cognitive-behavioural therapy for depression?
Eur Neuropsychopharmacol
December 2024
Federal University of Ceara, Brazil; Walter Cantídio University Hospital, Brazil. Electronic address:
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease.
J Nanobiotechnology
November 2024
Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, P. R. China.
Article Synopsis
- Mitochondrial dysfunction plays a significant role in inflammatory bowel disease (IBD), yet there are limited reports on targeted treatments that address this issue.
- Researchers developed a novel oral treatment called HA-Cr nanogel, which combines selenium and creatine to enhance mitochondrial energy metabolism and eliminate reactive oxygen species (ROS) specifically at inflammation sites.
- The HA-Cr nanogel showed promising results in improving IBD symptoms by restoring mitochondrial function, reducing inflammatory macrophage activity, repairing gut mucosa, and supporting microbial health, suggesting a new avenue for IBD treatment.
Levamisole Ameliorates Rheumatoid Arthritis by Downregulating the PI3K/Akt Pathway in SD Rats.
Pharmaceuticals (Basel)
November 2024
School of Pharmacy, Fujian Medical University, Fuzhou 350122, China.
Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease characterized by a protracted course, high rates of morbidity, and disability yet lacks effective therapeutic modalities. Levamisole (LVM), an immunomodulatory drug, has been clinically reported for its potential in RA treatment, while its therapeutic mechanism toward RA remains to be elucidated. Hence, this study provides theoretical support for the application of LVM in the treatment of RA.
View Article and Find Full Text PDFNigella sativa oil attenuates inflammation and oxidative stress in experimental myocardial infarction.
BMC Complement Med Ther
October 2024
Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, "Iuliu Haţieganu" University of Medicine and Pharmacy, Victor Babeș, No 8, Cluj-Napoca, 400012, Romania.
Background: A growing interest in using Nigella sativa oil (NSO) in the prevention or treatment of several cardiovascular diseases has prompted this study. The research aims to investigate the effect of NSO on cardiac damage prevention after long-term administration in induced myocardial infarction (MI) in rats.
Methods: NSO was analyzed for its fatty acids composition using gas chromatography-mass spectrometry (GC-MS) analysis and administered in rats before and after isoproterenol (45 mg/kg body weight) induced myocardial infarction.
Acute tubulointerstitial nephritis induced by intravesical bacillus Calmette-Guerin: a rare case of acute kidney injury.
Eur Rev Med Pharmacol Sci
September 2024
Department of General and Transplant Surgery, Students' Scientific Section, Poznan University of Medical Sciences, Poznan, Poland.
Article Synopsis
- Intravesical bacillus Calmette-Guerin (IVBCG) is a common therapy for high-risk urothelial cancers, typically causing mild side effects, but a rare case of acute renal failure from acute tubulointerstitial nephritis (ATIN) emerged following treatment.
- A 64-year-old male with high-grade papillary urothelial carcinoma experienced acute kidney injury and hematuria after his first IVBCG dose, with tests revealing significant kidney dysfunction and its related complications.
- The patient was treated with a combination of corticosteroids and antibiotics, requiring hemodialysis, and after two weeks, showed substantial recovery with improved kidney function.
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