Background: Partner services (PS) have been integral to syphilis control in the U.S. since the early 20th century but have not been evaluated in a controlled study.
Methods: We compared PS outcomes among gay, bisexual, and other men who have sex with men (GBMSM) diagnosed with syphilis from May 2020-June 2021 for whom health department staff initiated PS efforts (PS group) and a randomly selected control group for whom no PS efforts were initiated. We interviewed participants about partner outcomes and used chi-square tests and Poisson regression to test for differences in outcomes between groups.
Results: We attempted to contact 350 GBMSM and offered participation to 184 men, of whom 92 (51%) participated, including 41 men in the PS group and 51 controls. The percentage of participants who reported notifying >1 sex partner after diagnosis was similar in the PS and control groups (83% vs. 80%, p = 0.80). Mean number of partners notified or tested did not differ between PS and control groups (notified mean[range]: 2.5 [0-10] vs 3.3 [0-20], p = 0.16; tested mean[range]: 1.2 [0-8] vs. 1 [0-10], p = 0.66); multivariate results were similar. Among those contacted for PS, approximately half (48%) reported PS staff helped them with medical care for syphilis, and 31% said that PS staff connected them to PrEP.
Conclusions: This small, controlled evaluation suggests that syphilis PS may have no impact on partner treatment among GBMSM, though most men support the intervention. A randomized trial is needed to definitively define the contemporary effectiveness of syphilis PS among GBMSM.
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http://dx.doi.org/10.1097/OLQ.0000000000002132 | DOI Listing |
Diabet Med
January 2025
Department of Psychology, University of Southern Denmark, Odense, Denmark.
Int J Lang Commun Disord
January 2025
Division of Communication Sciences and Disorders, University of Cape Town, Rondebosch, South Africa.
Background: There is a global need for synthetic speech development in multiple languages and dialects, as many children who cannot communicate using their natural voice struggle to find synthetic voices on high-technology devices that match their age, social and linguistic background.
Aims: To document multiple stakeholders' perspectives surrounding the quality, acceptability and utility of newly created synthetic speech in three under-resourced South African languages, namely South African English, Afrikaans and isiXhosa.
Methods & Procedures: A mixed methods research design was selected.
Nat Med
January 2025
Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Cirrhosis is a major cause of morbidity and mortality; however, there are no approved therapies except orthotopic liver transplantation. Preclinical studies showed that bone-marrow-derived macrophage injections reduce inflammation, resolve fibrosis and stimulate liver regeneration. In a multicenter, open-label, parallel-group, phase 2 randomized controlled trial ( ISRCTN10368050 ) in n = 51 adult patients with compensated cirrhosis and Model for End-Stage Liver Disease (MELD) score ≥10 and ≤17, we evaluated the efficacy of autologous monocyte-derived macrophage therapy (n = 27) compared to standard medical care (n = 24).
View Article and Find Full Text PDFNPJ Precis Oncol
January 2025
Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Precision oncology offers new cancer treatment options, yet sequencing methods vary in type and scope. In this study, we compared whole-exome/whole-genome (WES/WGS) and transcriptome sequencing (TS) with broad panel sequencing by resequencing the same tumor DNA and RNA as well as normal tissue DNA for germline assessment, from 20 patients with rare or advanced tumors, who were originally sequenced by WES/WGS ± TS within the DKFZ/NCT/DKTK MASTER program from 2015 to 2020. Molecular analyses resulted in a median number of 2.
View Article and Find Full Text PDFEmerg Med J
January 2025
Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
Objective: Care partners play a vital role in supporting persons living with dementia (PLWD) in using medical services. We conducted a meta-synthesis to explore care partner perspectives of ED care for PLWD, as well as healthcare provider (HCP) perceptions of care partner roles within the ED, to identify care gaps and facilitators across the ED continuum.
Methods: MEDLINE, PsycINFO and Embase databases were searched from inception to 8 May 2023.
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