Simultaneous Prediction of Multiple Unmeasured Muscle Activations through Synergy Extrapolation.

Estimating muscle forces is crucial for understanding joint dynamics and improving rehabilitation strategies, particularly for patients with neurological disorders who suffer from impaired muscle function. Muscle forces are directly proportional to muscle activations, which can be obtained using electromyography (EMG). EMG-driven modeling estimates muscle forces and joint moments from muscle activations. While surface muscles? activations can be obtained using surface electrodes, deep muscles require invasive methods and are not readily available for real-time applications. This study aims to extend our previously developed method for a single unmeasured muscle to a comprehensive approach for the simultaneous prediction of multiple unmeasured muscle activations in the upper extremity using muscle synergy analysis and EMG-driven modeling. By employing non-negative matrix factorization to decompose known EMG data into synergy components, the activations of unmeasured muscles are reconstructed with high accuracy by minimizing differences between joint moments obtained by EMG-driven modeling and inverse dynamics. This methodology is validated through experimentally collected muscle activations, demonstrating over 90% correlation with EMG signals in various scenarios.