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Clinical feasibility study of transcatheter edge-to-edge mitral valve repair in dogs with the canine V-Clamp device. | LitMetric

Clinical feasibility study of transcatheter edge-to-edge mitral valve repair in dogs with the canine V-Clamp device.

Front Vet Sci

Department of Clinical Sciences and James L. Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Published: December 2024

AI Article Synopsis

Article Abstract

Objective: To determine procedural feasibility, safety, and short-term efficacy in dogs with severe degenerative mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) with a canine-specific device.

Design: Prospective, single-arm (uncontrolled), single-institution clinical feasibility study.

Animals: Fifty client-owned dogs with severe degenerative MR operated over a 28-month period.

Methods: TEER was performed using the canine mitral V-Clamp via a transapical approach using transesophageal echocardiographic and fluoroscopic guidance. Indices of MR severity were determined by echocardiography the day before and 2 to 3 days after the procedure.

Results: Procedural feasibility was 96% based on delivery of at least one device in 48 of 50 dogs. There were no procedural deaths. Procedural safety was 96% based on survival to hospital discharge in 48 of 50 dogs. Euthanasia in 2 dogs prior to hospital discharge was due to damage of the mitral valve and worsened MR after the procedure. Device-related adverse event rate was 6.3% based on 3 events (single-leaflet device detachment, locking failure, locking failure with device embolization) in 59 implanted devices. All three events were nonfatal and successfully treated with a second device. Median regurgitant volume (mL/kg) decreased ( < 0.001) from 2.3 [1.9, 3.1] to 1.1 [0.3, 1.8]. Median effective regurgitant orifice area (cm/m) decreased ( < 0.001) from 0.60 [0.40, 0.80] to 0.25 [0.10, 0.50].

Conclusion And Clinical Importance: Initial feasibility results support continued development of TEER as a procedurally feasible, relatively low-risk, and low morbidity treatment for degenerative MR in dogs. Operator experience and case selection are likely to be important components of success of this technique. Evidence of short-term efficacy is promising but needs to be verified with longer-term follow up.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663856PMC
http://dx.doi.org/10.3389/fvets.2024.1448828DOI Listing

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