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Severe traumatic brain injury (TBI) poses significant public health challenges, but treatments like neurofeedback and hyperbaric oxygen therapy (HBOT) show promise in aiding recovery. Neurofeedback enhances brain healing through operant conditioning, while HBOT increases cerebral oxygenation, supporting cognitive recovery. A 33-year-old woman, after suffering a severe TBI in 2018 and a long rehabilitation, began HBOT and neurofeedback in late 2021. By early 2022, she demonstrated significant cognitive, emotional, and social improvements. After numerous sessions, a June 2024 quantitative electroencephalogram (qEEG) revealed substantial brain recovery, with marked gains (Peterson et al.'s initial study) in daily functioning and specific tasks. This secondary analysis conducted in November 2024 used principal component analysis (PCA) on the initial pretest, posttest, and difference score data from the treatment period to explore the neurophysiological effects of the combined therapies. The results showed notable factor structure differences in brainwave patterns and electrode activity from the pretest to the posttest. The simpler structure observed in pretests evolved into a more complex factor structure with posttest and difference scores, indicating neurophysiological adaptations due to the interventions. This study's PCA findings align with the post-treatment qEEG statistical results conducted in June 2024 (Peterson et al.'s initial study), which identified moderate to large improvement effect sizes in the patient's brain's average frequency band parameters (g = 0.612) and small to moderate effect sizes on 19 electrode placement outcomes (uV² g = 0.339 and Hz g = 0.333). The June 2024 results indicated significant progress over a 31-month treatment period. In June 2024, the Disability Rating Scale (DRS) and the Glasgow Outcome Scale Extended (GOSE) showed substantial improvements in cognitive abilities such as feeding, toileting, grooming, and communication skills. According to the qEEG effect sizes, as well as DRS and GOSE scores from the pretest (2021) and posttest (2024), the patient demonstrated meaningful gains in brain recovery and overall quality of life. The cognitive improvements identified in the June 2024 Wilcoxon test were further corroborated by the factor structure analysis conducted in the November 2024 PCA. This alignment between the Wilcoxon test results and the PCA findings underscores the robustness of the observed cognitive gains, providing a comprehensive validation of the patient's progress. The consistency across these distinct analytical methods highlights the significant strides made in cognitive function, reinforcing the efficacy of the treatment regimen over the observed period.
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http://dx.doi.org/10.7759/cureus.74305 | DOI Listing |
J Infect Dis
December 2024
Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima City, Fukushima 960-1295, Japan.
Background: Amino acid (AA) substitutions in the fusion protein of respiratory syncytial virus (RSV) and their effects remain unclear. We aimed to analyze AA substitutions in main neutralizing epitopes of the fusion (F) protein.
Methods: We analyzed F protein genes of 236 RSV strains isolated from children hospitalized with RSV infection in Fukushima, Japan (June 2008-February 2023).
JMIR Public Health Surveill
December 2024
Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, United States.
Background: Convenience, privacy, and cost-effectiveness associated with web-based data collection have facilitated the recent expansion of web-based survey research. Importantly, however, practical benefits of web-based survey research, to scientists and participants alike, are being overshadowed by the dramatic rise in suspicious and fraudulent survey submissions. Misinformation associated with survey fraud compromises data quality and data integrity with important implications for scientific conclusions, clinical practice, and social benefit.
View Article and Find Full Text PDFIntern Med J
December 2024
Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Excipients have been identified as 'inert' substances that often enhance the non-pharmacological aspects of a medication. However, recent clinical evidence elucidates their potential in inducing anaphylaxis and indicates that they are often overlooked as potential allergens in routine clinical practice. The aim of the study was to assimilate published evidence on excipient-induced allergies associated with the use of oral medications and to underline their potential as potent allergens.
View Article and Find Full Text PDFAngiogenesis
December 2024
Service de Génétique et centre de reference de la maladie de Rendu-Osler, Hôpital Femme-Mère-Enfants, Hospices Civils de Lyon, Bron, France.
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist, nintedanib, is a good candidate thanks to its anti-angiogenic activity. Our main objective was to evaluate the efficacy of oral nintedanib on epistaxis duration in HHT patients with moderate to severe epistaxis.
View Article and Find Full Text PDFThe Liver Imaging Reporting and Data System (LI-RADS) was developed to standardize the interpretation and reporting of liver observations in at-risk populations, aiding in the diagnosis of hepatocellular carcinoma (HCC). Despite its advantages, the application of LI-RADS can be challenging due to the complexity of liver pathology and imaging interpretation. This comprehensive review highlights common pitfalls encountered in LI-RADS application and offers practical strategies to enhance diagnostic accuracy and consistency among radiologists.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!