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The effect of silymarin on diabetes mellitus-induced male rats reproductive impairment: Evidences for role of heat shock proteins 70 and 90.
Pol J Vet Sci
December 2024
Department of Basic sciences, Faculty of Veterinary Medicine, Tabriz medical sciences branch, Islamic Azad University, 5159115705, Tabriz, Iran.
Male fertility is adversely influenced by diabetes. The beneficial effects of antioxidant bioflavonoids in improving fertility have been reported. This study was conducted to evaluate the effects of silymarin on diabetes mellitus-induced male reproductive impairment in rats by investigating its role in Hsp70 and Hsp90 expression.
View Article and Find Full Text PDFSpinal Metastases in Non-Seminomatous Germ Cell Testicular Tumors: Prognosis and Integrated Therapeutic Approaches-A Systematic Review with an Institutional Case Illustration.
Curr Oncol
November 2024
Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy.
(1) Background: Testicular cancer, although accounting for only 0.5% to 1% of all solid male cancers, is the most common malignancy in males aged 15 to 35 years. Non-seminomatous germ cell tumors (NSGCT) represent nearly half of all testicular germ cell tumors and are associated with a more aggressive clinical course.
View Article and Find Full Text PDFHistopathological and Immunohistochemical Evaluation of Methotrexate-Induced Gonadal Damage in Rats: Role of SCF, mTOR, and SIRT-1.
Medeni Med J
December 2024
Erciyes University Faculty of Medicine, Histology and Embriyology, Kayseri, Türkiye.
Objective: Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. Our study used histopathological and immunohistochemical methods to assess the potential damage to testicular and ovarian tissue caused by MTX use.
View Article and Find Full Text PDF[Clinical characteristics and prognosis of children with T-lineage acute lymphoblastic leukemia: a single-center study].
Zhongguo Dang Dai Er Ke Za Zhi
December 2024
Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510000, China.
Objectives: To study the clinical characteristics and prognosis of T-lineage acute lymphoblastic leukemia (T-ALL) and related prognostic factors.
Methods: A retrospective analysis was conducted on the children with T-ALL who were treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia (CCCG-ALL) regimen in Guangzhou Women and Children's Medical Center between April 2015 and December 2022.
Results: A total of 80 children were included, with a median age of 7 years and 3 months and a male/female ratio of 6:1.
Mucinous Cystadenoma Arising in Post-Treatment Non-Seminomatous Germ Cell Tumor: A Rare Occurrence.
Cureus
November 2024
Pathology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Germ cell tumors, the most common of the testicular neoplasms, originate from primordial germ cells. These tumors are known for their totipotent nature, capable of differentiating into various cell types. This case report presents a rare occurrence of mucinous cystadenoma in a patient who received chemotherapy for metastatic left non-seminomatous germ cell tumor (NSGCT) of the testis.
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