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http://dx.doi.org/10.1016/j.jbspin.2024.105834 | DOI Listing |
Joint Bone Spine
December 2024
Department of Internal Medicine, Hôpital Lyon Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, France; Research on Healthcare Performance (RESHAPE), INSERM U1290, University Claude Bernard Lyon 1, 69100 Lyon, France. Electronic address:
J Immunother Cancer
June 2024
Rheumatology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands.
Introduction: Treatment with the immune checkpoint inhibitor anti-programmed cell death protein-1 (PD-1) often causes immune-related adverse events (irAEs). Since irAEs resemble autoimmune diseases, autoantibodies might play a role and could potentially be used to identify patients at risk. Therefore, we investigated the association between autoantibody-positivity and toxicity as well as clinical response in patients with melanoma treated with anti-PD-1.
View Article and Find Full Text PDFRheumatology (Oxford)
November 2024
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Objective: Individuals positive for anti-cyclic-peptide-antibodies (anti-CCP) and musculoskeletal complaints (MSK-C) are at risk for developing rheumatoid arthritis (RA). In this study we aimed to investigate factors involved in arthritis progression.
Methods: Anti-CCP2-positive individuals with MSK-C referred to a rheumatologist were recruited.
Objective: Patients with established rheumatoid arthritis (RA) demonstrate altered immune responses to Epstein-Barr virus (EBV), but the presence and roles of EBV have not been fully explored during the pre-clinical disease period. This study was undertaken to determine if EBV infection, as evidenced by an altered anti-EBV antibody response, either plays an important role in driving the development of RA or is a result of expanded RA-related autoimmunity.
Methods: A total of 83 subjects with RA according to the 1987 American College of Rheumatology (ACR) criteria and 83 age-, sex-, and race-matched control subjects without RA were included in our study.
Front Immunol
September 2021
Department of Medicine Solna, Division of Rheumatology, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g.
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