Background: Hypoglycaemia is one of the most common complications during the neonatal period. Recurrent hypoglycaemia episodes can result in neurodevelopmental deficits and even sudden death. Available evidence indicates that healthcare professionals ought to promptly assess the risk of hypoglycaemia in newborns immediately following birth and formulate the most suitable preventive strategies. Consequently, this study was designed to develop a clinical nursing decision support system for neonatal hypoglycaemia prevention based on the prediction model for neonatal hypoglycaemia risk that was developed in a previous study, and to evaluate its efficacy.
Methods: Nursing process as the theoretical framework, based on evidence-based nursing, standardized nursing language, and clinical decision support technology, the neonatal hypoglycaemia prevention nursing decision support system was developed.This system was implemented in the neonatology department of a tertiary grade A general hospital from September 1st to 30th, 2023.The application efficacy of the system was assessed and compared through the examination of the incidence of neonatal hypoglycemia, adverse outcomes associated with neonatal hypoglycemia, and the experiences of nurses following the implementation of the system.
Results: The incidence of neonatal hypoglycaemia decreased after the system was implemented, and the difference was statistically significant (X = 4.522, P = 0.033). None of the neonates experienced adverse outcomes during hospitalization. The rate of hypoglycaemia risk assessment in neonates after system implementation was 92.16%. The total Clinical Nursing Information System Effectiveness Evaluation Scale score was 104.36 ± 1.96.
Conclusion: The neonatal hypoglycaemia prevention nursing decision support system realizes neonatal hypoglycaemia risk assessment, intelligent decision-making, and effect evaluation, effectively diminishes the incidence of neonatal hypoglycaemia, and enhances the standardization of neonatal hypoglycaemia management.
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http://dx.doi.org/10.1186/s12911-024-02826-3 | DOI Listing |
J Family Med Prim Care
December 2024
Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
The Kabuki syndrome (KS) is a rare congenital disease that has two different types, KS1 and KS2, with variant in epigenetic gene KMT2D and KDM6A, respectively. It is associated with multiple abnormalities such as (developmental delay, atypical facial features, cardiac anomalies, minor skeleton anomalies, genitourinary anomalies, and mild to moderate intellectual disability). This syndrome can lead to neonatal hypoglycemia that results from hyperinsulinemia and electrolyte abnormalities.
View Article and Find Full Text PDFOrphanet J Rare Dis
January 2025
Laboratory of Metabolic Diseases, Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Postbus, Groningen, 30001 - 9700 RB, the Netherlands.
Background: Glycogen storage disease (GSD) Ia is an ultra-rare inherited disorder of carbohydrate metabolism. Patients often present in the first months of life with fasting hypoketotic hypoglycemia and hepatomegaly. The diagnosis of GSD Ia relies on a combination of different biomarkers, mostly routine clinical chemical markers and subsequent genetic confirmation.
View Article and Find Full Text PDFDiabetes Care
January 2025
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Objective: Subtypes of gestational diabetes mellitus (GDM) based on insulin sensitivity and secretion have been described. We addressed the hypothesis that GDM subtypes are differentially associated with newborn and child anthropometric and glycemic outcomes.
Research Design And Methods: Newborn and child (age 11-14 years) outcomes were examined in 7,970 and 4,160 mother-offspring dyads, respectively, who participated in the Hyperglycemia and Adverse Pregnancy Outcome Study (HAPO) and Follow-Up Study.
Clin Pediatr Endocrinol
January 2025
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
The ATP-binding cassette transporter subfamily C member 8 (ABCC8) regulates insulin secretion from β-cells. Loss- and gain-of-function variants of have been implicated in neonatal hyperinsulinemic hypoglycemia and young-onset diabetes, respectively. Although some patients with variants have been reported to exhibit both neonatal hypoglycemia and young-onset diabetes, the molecular and clinical characteristics of this atypical phenotype remain unknown.
View Article and Find Full Text PDFLife (Basel)
December 2024
Department of Neonatology, Emergency County Hospital Bihor, 410167 Oradea, Romania.
Background And Objective: The effects of neonatal hypoglycemia on the developing brain are well known, resulting in poor neurological outcomes. We aimed to perform an updated meta-analysis on neonatal hypoglycemia, the severity of hypoglycemia, and the associated neurodevelopmental outcomes from infancy to adulthood.
Methods: A systematic literature search was conducted from inception until March 2024, using the PubMed, CINAHL, Embase, and the CENTRAL databases.
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