Hair is a ubiquitous and robust mammalian tissue with biological, clinical, forensic, social, and economic significance. The hair shaft proteome reflects both structural proteins, dominated by cuticular intermediate filament keratins and associated proteins, and proteins involved in the final cellular processes of terminally differentiating corneocytes prior to cornification. These distinct biological processes involve cell maintenance, biosynthesis, senescence, and xenobiotic response. Because growth occurs rapidly and predictably, there is also temporal organization. The hair shaft proteome also contains genetic and phylogenetic information in the amino acid sequence. Chemically the shaft is highly robust, the result of a highly structured protein matrix with abundant isopeptide and disulfide intermolecular bonds. Sample processing is therefore a challenge that requires robust chemistries but also minimizes the introduction of additional chemical modifications. This protocol depends on the combination of sodium dodecanoate and high levels of reductant to denature the matrix. The result is a proteome that is both readily accessible and can provide biological information to geneticists, developmental biologists, toxicologists, human and wildlife forensic scientists, scientists in the cosmetics industry, and wildlife ecologists.
Hair is a ubiquitous and robust mammalian tissue with biological, clinical, forensic, social, and economic significance. The hair shaft proteome reflects both structural proteins, dominated by cuticular intermediate filament keratins and associated proteins, and proteins involved in the final cellular processes of terminally differentiating corneocytes prior to cornification. These distinct biological processes involve cell maintenance, biosynthesis, senescence, and xenobiotic response.
Hair color is formed through a series of processes such as melanin synthesis and storage in melanosomes, transfer from melanocytes, and reception by hair matrix cells in the hair bulb. Because gray hair is caused by the deterioration of a single or multiple of these processes, understanding the mechanisms responsible for these processes is crucial for developing therapeutic strategies. Recently, a robust approach for preparing hair follicle organoids (HFOs) was reported, in which hair follicle morphogenesis, including hair shaft elongation, was tracked in vitro.
Background: Androgenetic Alopecia (AGA) refers to the appearance of common non-scarring progressive loss of terminal hair. Trichoscopy shows a magnified view of the hair shafts and hair follicle openings and helps us to diagnose, prognosticate and determine the disease severity.
Aims: The aim of the study was to identify the trichoscopic findings in patients with androgenetic alopecia and associate these findings with disease severity.
Background: Plica neuropathica (PN) is an acquired hair disorder characterized by sudden onset, irreversible hair matting, which seems to be a compact hair mass with irregular twists.
Aim And Objective: This study aimed to evaluate the clinicodemographic features of PN.
Materials And Methods: This study was a cross-sectional prospective clinical research that included patients with PN.
