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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
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Background: Yellow nail syndrome (YNS) is a rare disorder characterized by a triad of yellow dystrophic nails, lymphedema, and chronic lung disease. Most patients present in adulthood, with only a few congenital or familial cases described. The cause of YNS remains largely unknown, although defects in lymphatic vessel development are suggested to play a significant role.
Objective: To elucidate the genetic mechanisms underlying YNS.
Design: Analysis of genetic sequencing data and gene and protein expression studies.
Setting: A tertiary care academic medical center.
Patients: 6 patients with congenital YNS (cYNS) and 5 with sporadic YNS (sYNS).
Measurements: Exome and genome sequencing were used to detect disease-causing variants, complemented by RNA analyses for intronic variants. Protein and gene expressions were studied by immunofluorescence staining and real-time reverse transcriptase quantitative polymerase chain reaction analyses.
Results: Biallelic variants in ( = 5) or likely ( = 1), both core molecules in the Wnt/planar cell polarity (PCP) pathway, were identified in all patients with cYNS; none of the patients with sYNS had candidate genetic variants. Immunofluorescence staining showed that CELSR1 colocalizes with lymphatic vessels in the skin but not in the lungs or the intestine. Moreover, levels of CELSR1 and FZD6 proteins were negligible to zero in patient tissues ( = 2) compared with control tissues. Gene expression of Wnt/PCP-related genes was reduced in patients with cYNS ( = 3), and patients with sYNS ( = 4) showed milder gene expression impairments.
Limitation: Small cohort size and limited sample availability.
Conclusion: Defects in PCP organization may play a major role in the pathogenesis of YNS. To the authors' knowledge, this is the first demonstration of a mechanism explaining YNS development, mainly in its congenital form but also in patients with sporadic disease.
Primary Funding Source: The Prof. Baum Research Fund of Israel Lung Association.
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Source |
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http://dx.doi.org/10.7326/ANNALS-24-01101 | DOI Listing |
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