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Hypoglycaemia following physical exercise in a patient with novel SLC16A1 variant. | LitMetric

AI Article Synopsis

Article Abstract

Rare defects in the promoter region of SLC16A1, the gene encoding monocarboxylate transporter 1 (MCT-1), result in exercise-induced hyperinsulinism. In this disorder inappropriate insulin secretion is triggered by anaerobic exercise with consequent hypoglycaemia. We describe the case of a 41 year old man presenting with a generalised tonic clonic seizure and severe hypoglycaemia following strenuous exercise. A subsequent prolonged fast with incorporation of exercise into the protocol demonstrated hyperinsulinaemic hypoglycaemia; genetic testing revealed a variant of unknown significance in the SLC16A1 gene. Administration of subcutaneous octreotide resulted in dose dependent reduction in hyperinsulinaemia and hypoglycaemia.

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http://dx.doi.org/10.1093/ejendo/lvae159DOI Listing

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