The impact of acquired immunodeficiency in a patient with b-cell chronic lymphocytic leukemia on the course of coronavirus disease (COVID-19): a case report. | LitMetric
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder that affects the bone marrow, lymph nodes, and spleen, and is associated with certain complications. One of the complications of CLL is acquired immunodeficiency, leading to a predisposition for prolonged respiratory viral and bacterial infections. This publication presents a clinical case of a prolonged and severe course of COVID-19 in a patient with CLL, who was successfully treated with immunoglobulin replacement therapy.
Use of cannabis and alcohol were common during pregnancy and the first year postpartum among people with HIV in the United States (2007-2019), but there were no major differences in substance use during pregnancy based on mode of HIV acquisition. The relatively high prevalence of substance use in this population, particularly postpartum alcohol and cannabis use, warrants further attention.
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder that affects the bone marrow, lymph nodes, and spleen, and is associated with certain complications. One of the complications of CLL is acquired immunodeficiency, leading to a predisposition for prolonged respiratory viral and bacterial infections. This publication presents a clinical case of a prolonged and severe course of COVID-19 in a patient with CLL, who was successfully treated with immunoglobulin replacement therapy.
Background: In acquired immunodeficiency syndrome patients, Talaromyces marneffei infections are mostly disseminated and may involve the skin, mucosa, respiratory system, digestive system, lymphatic system, and as some reports indicate, the nervous system. Mp1p, a cell wall-specific polysaccharide in Talaromyces marneffei, is used for laboratory diagnosis of Talaromyces marneffei in blood and urine samples. However, Cerebrospinal fluid Mp1p diagnosis of Talaromyces marneffei central nervous system infection has not been reported.
Trace elements (TEs) are essential for human health and for maintaining immune responses against potentially aggressive pathogens, such as the human immunodeficiency virus (HIV). During the infectious process, the body needs greater amounts of TEs in order to coordinate an efficient immune response to combat the invading agent, a condition that reflects in lymphocyte proliferation and activation of the antioxidant defense system of neutrophils and macrophages. Thus, during the progression phase of a viral infection, immunomodulation of TEs such as iron, zinc, chromium, magnesium, selenium, copper, calcium, and manganese occurs, can lead to immunosuppression and increased oxidative stress.
The body has a collection of physical barriers to prevent infection, but once these are overcome, we rely on our immune systems to protect us against a wide variety of infections. The complex mechanisms through which this is achieved are grouped into two lines of defense called the "innate" and "adaptive" immune systems. The innate immune system provides a rapid and tailored response to infection or injury often associated with inflammation.
