AI Article Synopsis
- The study investigates how β-tricalcium phosphate affects bone healing in rabbit mandibles after a defect is created.
- The research involved adult male rabbits, comparing a control group with a natural healing process against an experimental group treated with β-tricalcium phosphate over an 84-day period.
- Results showed significant regenerative changes in the experimental group, leading to an increase in bone tissue volume that ultimately matched the control group by the end of the study.
Article Abstract
Objective: Aim: The aim of this study is to determine the dynamics of histoarchitectural changes in the bone-ceramic regenerate after transplantation β-tricalcium phosphate into an experimental defect in the rabbit mandible.
Patients And Methods: Materials and Methods: Adult male rabbits aged 6-7 months and weighing 2.5-3 kg were used for the study. The control group consisted of animals with a bone defect that healed under a blood clot. The experimental group consisted of rabbits in which the bone defect was filled with β-tricalcium phosphate. Post-traumatic monitoring was conducted over 84 days using scanning electron microscopy and morphometric analysis of three parameters of the regenerate.
Results: Results: Studying the surface relief characteristics of the experimental bone defect in the lower jaw after implantation of the β-tricalcium phosphate material revealed numerous regenerative changes that occurred after the injury and correlated with the dynamics of changes in the relative volume of bone tissue, osteoplastic material, and connective tissue in the regenerate. Morphometric analysis of the regenerate showed a phased character of the dynamics of changes.
Conclusion: Conclusions: The study found that the relative volume of bone tissue in the regenerate increased over time, and at the end of the experiment, it was statistically similar to the control group.
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| http://dx.doi.org/10.36740/WLek/197118 | DOI Listing |
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