Estudiante de Psicología, Universidade Federal de Juiz de Fora, Minas Gerais, Brasil.
Published: December 2024
AI Article Synopsis
Article Abstract
The use of psychotropic drugs has become a public health issue due to their high consumption worldwide. In the context of traditional populations, the literature on the use of these medications is scarce. This study presents a descriptive analysis of psychotropic drug use among Indigenous and Quilombola communities in the states of Minas Gerais, Rio Grande do Norte, Alagoas, and Piauí in Brazil. Data collection was conducted between March and June 2023 using two structured questionnaires with closed-ended questions applied during home visits. These questionnaires gathered sociodemographic profiles of the Indigenous and Quilombola communities and general psychotropic drug usage. Out of 335 individuals from the four states who responded to the questionnaires on general psychotropic drug use, 53 reported using these medications. The users were predominantly adult women with low educational attainment, older age, low income, and reliance on social programs. Antidepressants were the most commonly used therapeutic class. The study concludes that economic and social vulnerability is likely a significant factor in the social determinants of psychological distress and psychotropic drug use.
Objectives: This study evaluated the impact of different doses of gabapentin and pregabalin on fracture healing in a rat femoral shaft model, with histological, radiological, and biomechanical assessments.
Materials And Methods: Seventy male Wistar albino rats were divided into five groups: control, low-dose gabapentin (GBP-L, 300 mg/day), high-dose gabapentin (GBP-H, 3600 mg/day), low-dose pregabalin (PRG-L, 150 mg/day), and high-dose pregabalin (PRG-H, 600 mg/day), based on human equivalent doses. Bilateral femoral fractures were induced; the right femurs were prepared for radiological examination using microtomography, followed by histological analysis, whereas the left femurs were allocated for biomechanical testing.
Introduction: Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), a widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards a combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined with Chitosan-Au nanoparticles for chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted efficacy and minimizing side effects.
Dipeptides were constructed using hydrophobic amino acid residues following AMP prediction. After that Boc-modification was performed on the screened peptides and finally Boc-Phe-Trp-OMe and Boc-Trp-Trp-OMe were synthesized. Even though no inhibition zones were observed in agar well diffusion assays, minimum inhibitory concentration (MIC) analysis revealed anti-bacterial activity against both Gram-positive and Gram-negative bacteria, with MIC ranging from 230 to 400 μg/mL.
Anxiety disorders are one of the most common mental health pathologies in the world. They require searc h and development of novel effective pharmacologically active substances. Thus, the development of new approaches to the search for anxiolytic substances by artificial intelligence methods is an important area of modern bioinformatics and pharmacology.
Major depressive disorder (MDD) is one of the most common diseases affecting millions of people worldwide. The use of existing antidepressants in many cases does not allow achieving stable remission, probably due to insufficient understanding of pathological mechanisms. This indicates the need for the development of more effective drugs based on in-depth understanding of MDD's pathophysiology.
