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Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage.
Sci Rep
January 2025
Department of Radiology and Nuclear Medicine, University Hospital Brno, Brno, 625 00, Czechia.
Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhepatic biliary drainage (PTBD) and to develop a simple scoring system predicting survival from PTBD insertion. This single-centre retrospective study included 175 consecutive patients undergoing PTBD for extrahepatic CCA (perihilar and distal).
View Article and Find Full Text PDFDiacylglycerol kinase alpha regulates post-hepatectomy liver regeneration.
Sci Rep
January 2025
Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, N15 W7 Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.
Article Synopsis
- Diacylglycerol kinases (DGKs), specifically DGKα, are important in liver regeneration and tumor progression but their role in liver regeneration has been unclear.
- Research using DGKα knockout mice after a 70% liver removal showed these mice had worse outcomes, including higher enzyme levels, jaundice, and a death rate of around 40%.
- DGKα KO mice also showed impaired liver function, low energy levels, and reduced cell proliferation, highlighting DGKα’s crucial role in liver regeneration and suggesting it could be a target for therapy.
"Bone marrow-liver-spleen-type diffuse large B-cell lymphoma" presenting with cold autoimmune hemolytic anemia: a case report.
J Med Case Rep
December 2024
Department of Pathology, Faculty of Medicine, University of Colombo, Colombo 08, Sri Lanka.
Introduction: Primary bone marrow diffuse large B-cell lymphoma is a rare clinical entity, and the "bone marrow-liver-spleen" type of diffuse large B-cell lymphoma is rarer, with only a few published cases in literature. Though bone marrow-liver-spleen-type diffuse large B-cell lymphoma has unique presentations such as fever, cytopenias, and hemophagocytic lymphohistiocytosis, no cases with cold autoimmune hemolytic anemia have been reported.
Case Presentation: A 39-year-old Sri Lankan woman, previously healthy, presented with shortness of breath, productive cough, and fever for 4 days.
Thresholds for conjugated hyperbilirubinaemia and hepatobiliary scintigraphy in biliary atresia: A 12-year national follow-up.
Acta Paediatr
December 2024
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Aim: To investigate liver biochemistry in infants screened for biliary atresia (BA) at the time of hepatobiliary scintigraphy (HS) and to evaluate the effect of change in threshold for HS.
Methods: Infants born from 2010 to 2021, who underwent HS <6 months postpartum for BA, were included and data sourced from electronic medical records. The change in threshold in 2018 from ≥20 (and/or if conjugated bilirubin exceeds 20% of total bilirubin) to ≥17 μM (regardless of total bilirubin) was evaluated.
Challenges in management of abnormal thyroid function tests in unwell infants: A tertiary centre real-world experience.
J Paediatr Child Health
December 2024
The Children's Hospital Westmead, Sydney, New South Wales, Australia.
Aim: Abnormal thyroid function tests (TFTs) are found in a wide range of settings in hospitalised infants. This retrospective descriptive study reviewed management decisions and outcomes of these infants, identifying factors influencing clinicians' decision to treat with thyroxine.
Methods: Data were collected for all infants referred to the on-call endocrinology service at a tertiary Australian centre for thyroid dysfunction between 1 July 2019 and 30 June 2021.
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