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Peptide Nanocarriers for Targeted Delivery of Nucleic Acids for Cancer Therapy. | LitMetric

Peptide Nanocarriers for Targeted Delivery of Nucleic Acids for Cancer Therapy.

Bioconjug Chem

State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Published: December 2024

AI Article Synopsis

  • * The study enhanced a peptide vector by incorporating the RGD cancer-targeting peptide, allowing it to selectively target tumor cells expressing RGD-binding receptors.
  • * The modified delivery system successfully transported B-cell lymphoma-2 antisense oligonucleotides to RGD receptor-positive cells, leading to significant gene knockdown and demonstrating potential for targeted nucleic acid drug delivery.

Article Abstract

Peptides have been extensively studied in nanomedicine with great bioactivity and biocompatibility; however, their poor cell-membrane-penetrating properties and nonselectivity greatly limit their clinical applications. In this study, tumor-targeting therapy was achieved by modifying our previously developed efficient peptide vector with the cancer-targeting peptide RGD, enabling it to specifically target tumor cells with a high expression of RGD-binding receptors. B-cell lymphoma-2 antisense oligonucleotides were selected as the target model to validate the effectiveness of the delivery carriers. Results demonstrated that this delivery system can be efficiently and selectively taken up by RGD receptor-positive cells (αβ integrin receptor), further inducing effective target gene knockdown. Overall, this system provided a promising strategy for the targeted delivery of nucleic acid drugs.

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Source
http://dx.doi.org/10.1021/acs.bioconjchem.4c00324DOI Listing

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