AI Article Synopsis
- Streptococcus pneumoniae is an uncommon cause of arthritis in adults, with a study of 110 cases revealing notable characteristics of pneumococcal septic arthritis among patients aged around 65 years old in France during 2010-2018.
- The most affected joints were the knee and hip, and many patients experienced other pneumococcal infections and had underlying health conditions.
- The study highlighted a 9.4% mortality rate, 29.1% of strains showed resistance to penicillin, and new nonvaccine serotypes were identified, indicating a shift in susceptibility patterns.
Article Abstract
Streptococcus pneumoniae infection is considered an uncommon cause of arthritis in adults. To determine the clinical and microbiological characteristics of pneumococcal septic arthritis, we retrospectively studied a large series of cases among adult patients during the 2010-2018 conjugate vaccine era in France. We identified 110 patients (56 women, 54 men; mean age 65 years), and cases included 82 native joint infections and 28 prosthetic joint infections. Most commonly affected were the knee (50/110) and hip (25/110). Concomitant pneumococcal infections were found in 37.2% (38/102) and bacteremia in 57.3% (55/96) of patients, and underlying conditions were noted for 81.4% (83/102). Mortality rate was 9.4% (8/85). The proportion of strains not susceptible to penicillin was 29.1% (32/110). Of the 55 serotyped strains, 31 (56.4%) were covered by standard pneumococcal vaccines; however, several nonvaccine serotypes (mainly 23B, 24F, and 15A) had emerged, for which susceptibility to β-lactams was low.
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| http://dx.doi.org/10.3201/eid3101.240321 | DOI Listing |
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