AI Article Synopsis
- - The study explores the effectiveness of albendazole/ivermectin combination therapy for controlling Trichuris trichiura, suggesting it may be more effective than single benzimidazole treatment.
- - Genetic analysis of Trichuris populations in Côte d'Ivoire revealed that they are distinct from those in Laos and Tanzania, with lower sensitivity to treatment, and identified a new species called T. incognita.
- - The research highlights the need for ongoing monitoring to understand the distribution of Trichuris species and to inform future control strategies, especially given the zoonotic potential of T. incognita.
Article Abstract
Albendazole/ivermectin combination therapy is a promising alternative to benzimidazole monotherapy alone for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris spp. populations in patient samples from Côte d'Ivoire showing lower (egg reduction rate <70%) albendazole/ivermectin sensitivity than those from Laos and Tanzania (egg reduction rates >98%). Internal transcribed spacer (ITS) 1 and ITS2 metabarcoding revealed the entire detected Côte d'Ivoire Trichuris population was phylogenetically distinct from T. trichiura found in Laos and Tanzania and was more closely related to T. suis. Mitochondrial genome sequencing of 8 adult Trichuris worms from Côte d'Ivoire confirmed their species-level differentiation. Sequences from human patients in Cameroon and Uganda and 3 captive nonhuman primates suggest this novel species, T. incognita, is distributed beyond Côte d'Ivoire and has zoonotic potential. Continued surveillance by using fecal DNA metabarcoding will be needed to determine Trichuris spp. geographic distribution and control strategies.
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| http://dx.doi.org/10.3201/eid3101.240995 | DOI Listing |
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