Purpose: Oral squamous cell carcinoma is one of the most common types of cancer in the head and neck. Squamous cell carcinoma of the buccal mucosa is an important part of it. The traditional surgical method leads to great injury and is accompanied by unacceptable scars. Previous improvements have been carried out in a single part. Natural orifice specimen extraction surgery (NOSES) system could perform "scarless surgery" and reduce complications. This technique was usually used for transvaginal or transanal specimen retrieval. There is great potential for oral and maxillofacial applications, especially in the field of oral and maxillofacial surgery. We combine the 2 to achieve better surgical results.
Methods: The authors applied the NOSES system in the radical operation of buccal mucosa squamous cell carcinoma. Through FACE-LIFT incision, with the help of indocyanine green (ICG) and microscope, they successfully cured buccal mucosa squamous cell carcinoma.
Results: The patient was cured, and there was no recurrence after 1 year of follow-up. The incision is hidden, and the damage is small. The number of harvested lymph nodes in the pathologic examination was 1/18.
Conclusions: The application of the NOSES system in maxillofacial surgery has very obvious advantages. The surgical procedures follow the principles of aseptic and tumor-free techniques, making the tumor en-block dissection. For stage 1 patients, this scheme not only ensures the radical cure of the tumor but also improves the detection rate of lymph nodes and ensures the patients' appearance. For doctors, this program is easy to operate and learn and can reduce the peer gap.
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http://dx.doi.org/10.1097/SCS.0000000000010725 | DOI Listing |
Clin Oncol (R Coll Radiol)
December 2024
Radiation Oncology Network, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia. Electronic address:
Aims: Unresectable cutaneous squamous cell cancer of the head and neck (HNcSCC) poses treatment challenges in elderly and comorbid patients. Radiation therapy (RT) is often employed for locoregional control. This study aimed to determine progression-free survival (PFS) and overall survival (OS) outcomes achieved with upfront RT in unresectable HNcSCC.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Center for Nutritional Sciences, Food Science and Human Nutrition Department, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32611.
Documented worldwide, impaired immunity is a cardinal signature resulting from loss of dietary zinc, an essential micronutrient. A steady supply of zinc to meet cellular requirements is regulated by an array of zinc transporters. Deletion of the transporter Zip14 (Slc39a14) in mice produced intestinal inflammation.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Oncode Institute, Hubrecht Institute-Royal Netherlands Academy of Arts and Science, Utrecht 3584 CT, The Netherlands.
Matrigel/BME, a basement membrane-like preparation, supports long-term growth of epithelial 3D organoids from adult stem cells [T. Sato , , 262-265 (2009); T. Sato , , 1762-1772 (2011)].
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104.
Dorsal closure is a process that occurs during embryogenesis of . During dorsal closure, the amnioserosa (AS), a one-cell thick epithelial tissue that fills the dorsal opening, shrinks as the lateral epidermis sheets converge and eventually merge. During this process, both shape index and aspect ratio of amnioserosa cells increase markedly.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.
Postnatal establishment of enteric metabolic, host-microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infection with the invasive enteropathogen Typhimurium results in accelerated maturation of the neonatal epithelium with premature appearance of antimicrobial, metabolic, developmental, and regenerative features of the adult tissue. Using conditional Myd88-deficient mice, we identify the critical contribution of immune cell-derived mediators.
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