Malignant fibrous histiocytoma (MFH) is a malignancy originating from soft tissues and ranks among the most prevalent soft tissue sarcomas in adults. The considerable complexity and heterogeneity of MFH contribute to an obscure pathogenesis, presenting with atypical clinical manifestations and pathologic features that complicate the clinical diagnostic process. Typically, MFH manifests in the extremities, trunk, and retroperitoneum, while occurrences in the head and neck regions are exceedingly rare. A thorough review of extant literature indicates that fewer than 5 cases of MFH secondary to a documented history of trauma have been reported globally. This article delineates an exceptionally rare instance of secondary MFH of the head subsequent to trauma, elaborating on the diagnostic and therapeutic procedures undertaken. It seeks to enrich the understanding of MFH treatment and pathogenesis and, by reviewing pertinent literature, aims to elucidate the clinical characteristics and prognostic outlook of MFH.
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http://dx.doi.org/10.1097/SCS.0000000000011032 | DOI Listing |
Diagnostics (Basel)
December 2024
Department of Otorhinolaryngology, Medical University of Graz, Auenbruggerplatz 26, 8010 Graz, Austria.
This report describes a rare occurrence of benign fibrous histiocytoma in the frontal sinus of a 38-year-old male. The patient presented with acute symptoms, including sudden-onset headache, nausea, and general discomfort, although neurological, otorhinolaryngological and laboratory examinations showed no abnormalities. A cranial CT scan revealed a cystic, osteodestructive lesion measuring 2.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Rationale: Solitary fibrous tumors (SFTs) are spindle cell tumors that typically occur in the pleura and peritoneum, but very rarely in the stomach. To our best knowledge, there are only 10 cases reported in English literature. We reported a case of primary stomach SFT and summarized the characteristics of all previous cases, suggesting that pathologists and surgeons should include this disease in the differential diagnosis list of primary mesenchymal tumor of the stomach.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: The palmar aponeurosis is extremely adherent to the skin above it. Many of the pre-tendinous coarse fibers enter the dermis at an angle, not just in the palmar creases but also throughout the palm. It's difficult to distinguish whether Dupuytren's illness starts in the skin's dermis or the palmar aponeurosis since the skin adheres so closely to the palmar fascia.
View Article and Find Full Text PDFInt J Surg Pathol
January 2025
Department of Pathology, VCU School of Medicine, Richmond, VA, USA.
The proliferation of recognized neoplasms related to related to rearrangements involving kinase genes, arising in diverse somatic tissue lineages, poses an increasing challenge in surgical pathology. For instance, ALK rearrangements have been observed in diverse neoplasms of epithelial, connective tissue, and hematolymphoid lineages, many of which are associated with overexpression of ALK by immunohistochemistry as a useful biomarker. An even higher order challenge and pitfall would be the scenario where a tumor an ALK rearrangement nonetheless overexpresses the protein, thereby simulating an ALK-defined neoplasm.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
January 2025
Department of Pathology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing210011, China.
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