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Terlipressin-Induced Skin Necrosis of 3 Cases: Should We Concern?
Turk J Gastroenterol
December 2024
Departmant of Gastroenterology and Hepatology, Professor at Ondokuz Mayıs University Faculty of Medicine, Samsun, Türkiye.
Terlipressin-induced skin necrosis in cirrhotic patients-A case report and comprehensive literature review.
Clin Case Rep
October 2024
Department of Internal Medicine Hamad Medical Corporation Doha Qatar.
Article Synopsis
- Terlipressin, a drug used for conditions like portal hypertension, can cause rare but serious skin necrosis in patients with cirrhosis.
- Clinicians need to monitor cirrhotic patients closely for this complication and recognize it early to improve outcomes.
- More research is required to identify risk factors for this adverse effect and to create preventive measures, prompting healthcare providers to balance its benefits against potential risks.
Terlipressin is an analogue of vasopressin and is often used in the treatment of bleeding esophageal varices and also in the treatment of hepatorenal syndrome associated with liver cirrhosis. Although terlipressin is a safe drug, but it has been rarely associated with potentially serious adverse effects like ischemic necrosis of skin involving the abdominal skin, extremities, and scrotal skin. We present one such rare case where terlipressin-induced skin necrosis in bilateral lower extremities in a 48-year-old male while we were managing hepatorenal syndrome in the same.
View Article and Find Full Text PDFClinical characteristics and treatment of terlipressin-induced ischemic skin necrosis: A synthesis of 35 literature reported cases.
J Clin Pharm Ther
August 2022
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
What Is Known And Objective: The clinical features of terlipressin-induced ischemic skin necrosis are unknown. The purpose of this study is to explore the clinical features of terlipressin-induced skin necrosis.
Methods: We searched Chinese and English databases to collect case reports of terlipressin-induced skin necrosis for retrospective analysis.
Terlipressin-induced skin necrosis.
BMJ Case Rep
November 2021
Department of Anaesthesiology and Critical Care, AIIMS Rishikesh, Rishikesh, Uttarakhand, India
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