AI Article Synopsis
- L (Malvaceae) is a traditional Chinese medicine known for its strong anti-inflammatory properties.
- Researchers isolated three compounds from its flowers, including a newly identified flavonoid and two known flavonoids, using spectroscopic methods to determine their structures.
- The new flavonoid showed significant potential in reducing inflammation by inhibiting the production of inflammatory markers and key proteins associated with the NF-κB signaling pathway in lab-induced macrophage cells.
Article Abstract
L (Malvaceae) was a traditional Chinese medicine with significant anti-inflammatory activity. We isolated 3 compounds from the flowers of L , including a new flavonoid, (1″R)-8-(1-(3,4-dihydroxyphenyl)ethyl)-3,3',5,7-tetrahydroxy-4'-methoxyl flavone (), and 2 known flavonoids (). The structures of these compounds were elucidated by various spectroscopic methods. In addition, we evaluated the anti-inflammatory effect of compound . The bioactivity assay showed that significantly inhibit the excessive production of IL-6, TNF-α and NO in LPS-induced RAW264.7 macrophages. Western blot analysis demonstrated that inhibit the expressions of COX-2 and iNOS protein in the macrophages induced by LPS in a concentration-dependent manner. In addition, also significantly suppress the expression of the key proteins P65 and p-P65 in the NF-B signaling pathway. Our results revealed that exert potential anti-inflammatory activity through inhibiting the activation of NF-B signaling pathway.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662378 | PMC |
| http://dx.doi.org/10.1177/15593258241290130 | DOI Listing |
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