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Enhanced Electrochemiluminescence Detection of Dopamine Using Antifouling PEDOT-Modified SPEs for Complex Biological Samples. | LitMetric

Enhanced Electrochemiluminescence Detection of Dopamine Using Antifouling PEDOT-Modified SPEs for Complex Biological Samples.

ACS Meas Sci Au

Department of Materials Science and Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.

Published: December 2024

AI Article Synopsis

Article Abstract

Detecting medically important biomarkers in complex biological samples without prior treatment or extraction poses a major challenge in biomedical analysis. Electrochemical methods, specifically electrochemiluminescence (ECL), show potential due to their high sensitivity, minimal background noise, and straightforward operation. This study investigates the ECL performance of screen-printed electrodes (SPEs) modified with the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives for dopamine (DA) detection. PEDOT modification significantly enhances ECL intensity, improves sensitivity, and expands the linear range for DA detection. Functionalizing PEDOT with ethylene glycol (EG) further enhances stability, specificity, and resistance to interferences for DA detection. These modified SPEs demonstrate the linear range of 1-200 μM and a detection limit as low as 0.887 nM (/ = 3), surpassing many previous studies using SPEs. Moreover, the PEDOT-EG-OMe-modified SPEs can reliably detect DA in solutions with high protein concentrations or artificial cerebrospinal fluid. These results suggest that the PEDOT derivative-modified SPE can serve as reusable and sensitive DA sensors in complex biological environments, highlighting the potential of the ECL system for a range of challenging applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659998PMC
http://dx.doi.org/10.1021/acsmeasuresciau.4c00053DOI Listing

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