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Branch Retinal Artery Occlusion as a Presentation of Seronegative Antiphospholipid Syndrome in Pregnancy. | LitMetric

AI Article Synopsis

  • A 40-year-old woman who had experienced two miscarriages and was 14 weeks pregnant presented with visual problems in her right eye, leading to a diagnosis of right-eye retinal artery occlusion linked to seronegative antiphospholipid syndrome (APS).
  • Despite normal results for various blood tests and imaging, a magnetic resonance angiogram revealed significant internal carotid artery stenosis, indicating potential vascular issues.
  • The patient was treated with anticoagulation therapy during her pregnancy, which successfully improved her symptoms, and she delivered a healthy child while continuing medication post-partum; follow-up showed no significant vascular issues.

Article Abstract

A 40-year-old gravida 7 para 4+2 lady who was 14 weeks pregnant presented with a three-day history of sudden-onset flashes of light associated with a superonasal visual field defect on her right eye. She had two prior miscarriages that occurred in the second and third trimesters. Previous serological tests for antiphospholipid syndrome (APS) were normal. No other comorbidities were reported. On examination, visual acuity for both eyes was 6/6 with normal intra-ocular pressure. There was an embolus lodged at the inferotemporal peripheral retinal artery of the right eye with adjacent pale and oedematous distal retina. This corresponded with a superonasal scotoma on the Humphrey 30-2 visual field test. Other examinations were unremarkable. The patient was referred to obstetrics, rheumatology, and neuro-medical teams for co-management. Full blood count, coagulation profile, auto-immune panel, and antiphospholipid serological screening test were normal. No abnormalities were seen on her electrocardiogram and echocardiogram. A magnetic resonance angiogram of the brain revealed significant bilateral internal carotid stenosis at C2 and C6 levels. However carotid artery assessment showed normal flow below the jawline. The patient was diagnosed with seronegative APS with right-eye inferotemporal branch retinal artery occlusion (BRAO). A multidisciplinary team monitored her pregnancy, and she was started on subcutaneous enoxaparin 40 mg twice a day and oral aspirin/glycine 100 mg/45 mg once daily. At 20 weeks of pregnancy, the Hollenhorst plaque disappeared, and the visual field defect started to improve. She went on to deliver a healthy child at 36+6 weeks. Post-partum, she has continued on oral aspirin 100 mg once daily. A carotid angiogram performed post-delivery showed no evidence of internal carotid artery stenosis or thrombosis. This case highlights the importance of recognizing BRAO as it can be the presentation of a previously unrecognized seronegative antiphospholipid syndrome. Early recognition of the correct diagnosis is vital to allow effective multidisciplinary management, especially when dealing with a patient in pregnancy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663242PMC
http://dx.doi.org/10.7759/cureus.74198DOI Listing

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