AI Article Synopsis
- The study presents the crystal structure of a glycosylated porphyrin system, where two galactose units are linked to a substituted tetra-aryl porphyrin, revealing a planar porphyrin framework with galactose groups positioned above and below it.
- This unique orientation prevents H-type aggregation between porphyrins, which may improve their effectiveness as photosensitizers for photodynamic therapy.
- The crystal network exhibits significant non-bonding interactions (C-H⋯O and C-H⋯π) and favorable π-π interactions between tolyl groups of adjacent porphyrins, contributing to the structural stability.
Article Abstract
The crystal structure of a glycosyl-ated porphyrin () system, CHNO, where two iso-propyl-idene protected galactose moieties are attached to the position of a substituted tetra-aryl porphyrin is reported. This structure reveals that the parent porphyrin is planar, with the galactose moieties positioned above and below the porphyrin macrocycle. This orientation likely prevents porphyrin-porphyrin H-type aggregation, potentially enhancing its efficiency as a photosensitizer in photodynamic therapy. Notable non-bonding C-H⋯O and C-H⋯π inter-actions among adjacent systems are observed in this crystal network. Additionally, the tolyl groups of each porphyrin can engage in π-π inter-actions with the delocalized π-systems of neighboring porphyrins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660175 | PMC |
| http://dx.doi.org/10.1107/S2414314624010289 | DOI Listing |
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