Biomarkers of Parkinson's Disease.

Background: Parkinson's disease (PD) is a degenerative brain disease characterised by motor and non-motor symptoms. Motor disabilities, including dystonia and dyskinesia, cause speech and movement difficulties and limit many aspects of life. Factors affecting PD refer to the various internal and external conditions that contribute to the onset, severity and progression of the disease. These factors can be broadly categorised into genetic, environmental and lifestyle-related factors.

Summary: The primary objective of this prospective cohort study is to investigate the association between environmental exposures and genetic predisposition and the risk of developing PD. Secondary objectives include examining the relationships between these factors and clinical outcomes in PD, such as disease severity and progression. We have utilised the data from other research studies, which primarily involve recruiting a cohort of individuals at high risk for PD based on their family history and/or environmental exposure history. These research studies also include participants who will undergo clinical evaluations, including neurological examinations and cognitive assessments, and provide biospecimens for genetic analysis. Environmental exposure histories will be obtained through questionnaires and medical records fetched by the authors of these research studies. In all these studies, participants were followed up regularly over several years to monitor the development of PD and to assess disease progression.

Key Message: This study provided valuable insights into the role of environmental exposures and genetic predisposition in the development and progression of PD. The results of this study may inform strategies for preventing or delaying the onset of PD in high-risk individuals, as well as guide the development of targeted interventions for those already diagnosed with the disease.