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Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy.
J Bras Nefrol
January 2025
Universidade Federal de São Paulo, Departamento de Medicina, São Paulo, SP, Brazil.
Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2-week history of fever, cervical adenopathy, and facial erythema. After admission, anemia, hypoalbuminemia, proteinuria, and severe acute kidney injury were noted.
View Article and Find Full Text PDFCollapsing glomerulopathy as a rare cause of rapidly progressive renal failure in adolescence: two case reports.
Hong Kong Med J
December 2024
Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Gazi University, Ankara, Turkey.
Article Synopsis
- * Among 94 patients, most were male and half had a history of hypertension; commonly observed kidney issues included collapsing glomerulopathy (CG), focal segmental glomerulosclerosis (FSGS), and thrombotic microangiopathy (TMA).
- * Results indicated that FSGS and minimal change disease (MCD) were linked to better kidney survival compared to TMA, underscoring differences in kidney complications resulting from COVID-19 within this patient group.
What is the spectrum of kidney pathology associated with COVID-19?
Intern Med J
December 2024
Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Article Synopsis
- * A review of 14 studies, covering 159 patients, showed that direct viral infection isn't the primary cause of kidney damage; instead, factors like specific genotypes among patients of African descent contribute to conditions like collapsing glomerulopathy.
- * Understanding COVID-19-related kidney problems is crucial for developing better treatment strategies and preventing chronic kidney disease, but more research is needed to grasp the long-term effects.
Role of baseline soluble tumor necrosis factor receptor 2 as a biomarker in primary podocytopathy: Implications for renal impairment and disease progression.
BMC Nephrol
October 2024
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.
Background: Podocytopathies, including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and collapsing glomerulopathy (CG), are kidney diseases that damage glomerular podocytes, leading to heavy proteinuria and nephrotic syndrome (NS). Inflammation plays a critical role in the progression of chronic kidney disease (CKD), with recent studies linking inflammatory biomarkers to declining kidney function. Tumor necrosis factor-alpha (TNF-α), an essential inflammatory cytokine, interacts with its circulating receptors, TNFR1 and TNFR2.
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