Background: A recent study highlighted variability in complication rates among polylactic acid (PLA)-based collagen stimulator fillers, with notably high rate of complications linked to PLLA-Elleva. The study suggested that product-specific characteristics might have greater impact on outcomes than injection techniques.
Methods/results: Through a critical analysis of pertinent literature, this commentary explores how PLLA-Elleva's unique physicochemical properties, particularly its bimodal degradation process, may contribute to the increased nodule formation observed.
Conclusion: Although PLLA-Elleva's degradation pattern does not inherently compromise safety, it introduces variability that requires careful attention to dosage, injection technique, and patient selection.
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| http://dx.doi.org/10.1111/jocd.16751 | DOI Listing |
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