Research progress on N-Methyladenosine modification in angiogenesis, vasculogenic mimicry, and therapeutic implications in breast cancer.

N-methyladenosine (mA) modification is the most common epitranscriptomic modification in eukaryotic RNA and has garnered extensive attention in the context of breast cancer research. The mA modification significantly impacts tumorigenesis and tumor progression by regulating RNA stability, splicing, translation, and degradation. In this review we summarize recent advances in understanding the roles of mA modification in the mechanisms underlying angiogenesis and vasculogenic mimicry in breast cancer. We review how mA modification and associated transcripts influence relevant factors by affecting key factors and signaling pathways, highlighting the interactions among mA "writers," "erasers," and "readers," and their overall impact on tumor angiogenesis and vasculogenic mimicry, as well as potential new therapeutic targets.