Advanced chitin-based composite hydrogels enabled by quercetin-mediated assembly for multifunctional applications.

Natural building blocks like chitins for self-assembling into complex materials have garnered significant interest owing to the inherent and diverse functionalities. However, challenges persist in the assembly of chitin-based composites, primarily stemming from chitin's poor solubility and compatibility. Herein, a quercetin-mediated multiple crosslinking strategy was developed to enhance compatibility by quercetin-mediated interfacial interactions between chitin and inorganic materials, achieving a series of chitin-based composite hydrogels with high performances. The quercetin-mediated strategy could effectively modulate the non-covalent interactions within hydrogel, which served as the sacrificial bonds to dissipate large energy, leading to the high toughness of chitin-based composite hydrogels (0.70-1.02 MJ·m). Furthermore, through utilizing quercetin-assisted non-covalent interactions, effective dispersion of inorganic materials (e.g., molybdenum disulfide, carbon nanotube and calcium carbonate) within hydrogels was achieved, resulting in composite hydrogels with diverse functionalities. Our quercetin-mediated strategy conceptualized in this work paves the way for the development of a diverse array of chitin-based composite hydrogels which incorporate various functional inorganic materials.