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| http://dx.doi.org/10.1530/JME-24-0124 | DOI Listing |
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Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways.
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Department of Ob/Gyn and Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Reproductive success requires accurately timed remodeling of the cervix to orchestrate the maintenance of pregnancy, the process of labor, and birth. Prior work in mice established that a combination of continuous turnover of fibrillar collagen and reduced formation of collagen cross-links allows for the gradual increase in tissue compliance and delivery of the fetus during labor. However, the mechanism for continuous collagen degradation to ensure turnover during cervical remodeling is still unknown.
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Department of Pediatrics, Toranomon Hospital, Tokyo, JPN.
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